soulseek dc++ mirc but now, i just check a forum where they post like yousendit, rapidshare, megaupload, etc... links.
I used to use Ares \'cause it rocks, but it crapped out. Now I use Limewire. Works fine I guess. Have you tried KaZaa?
I use Shareaza. It uses the same network as LimeWire (Gnutella 1), but also can connect to the updated Gnutella 2 network, the eDonkey network, and download BitTorrents. I like the servent\'s interface better and it doesn\'t need the Java framework like LimeWire.