Magic-mushroom drug can treat severe depression, trial suggests

Discussion in 'Science and Nature' started by Vee, Nov 3, 2022.

  1. [​IMG]
    Scientists have developed a synthetic form of psilocybin

    A drug based on a compound in hallucinogenic mushrooms can improve the symptoms of severe depression for up to 12 weeks, a trial shows.

    A 25mg tablet of psilocybin puts patients in a dreamlike state, making psychological therapy more likely to succeed.

    But the short-term side-effects could be frightening and support must always be on hand, the researchers said.

    Experts say larger studies with a much longer follow-up are still needed.

    An estimated 100 million people worldwide have serious clinical depression that does not respond to any available treatments - 30% attempt suicide.

    Scientists have been studying the effects of psilocybin on mental-health disorders for years.

    Recent studies have been promising but too short to assess lasting effects.

    In this latest trial, published in the New England Journal of Medicine, 1mg, 10mg and 25mg doses were tested on a total of 233 people from 10 countries in Europe and North America, with 25mg giving the best results.

    'Waking dream'
    Most had been severely depressed for more than a year and were aged around 40, the researchers, from the Institute of Psychiatry, Psychology and Neuroscience at King's College London and South London and Maudsley NHS Foundation Trust, said.

    After one 25mg dose of Comp360 psilocybin, alongside psychotherapy:

    • one in three were no longer diagnosed as depressed at three weeks
    • one in five saw a significant improvement at 12 weeks
    Study author and consultant psychiatrist Dr James Rucker said the drug was thought to have "a direct action on the brain, putting it into a more flexible state and providing an window of opportunity for therapy".

    The room where patients with severe depression were treated with a hallucinogenic drug in the trial

    The patients, lying on a bed in a calm room, experienced a psychedelic "trip" - which one described as "a waking dream" - for six to eight hours.

    "It can be very positive but it can also be negative," Dr Rucker told BBC News.

    "Difficult memories from the past can come up, for example, at the same time as feeling a reconnection with yourself and your feelings."

    A therapist was on hand to provide support.

    Safety concern
    The following day and a week later, the patients were given psychological support to talk through their experience.

    "Patients go from 'What is wrong with me?' to 'What happened to me?'" psychotherapist Nadav Liam Modlin said.

    Some patients in all groups experienced side-effects, such as headaches, nausea, extreme tiredness as well as thoughts about suicide.

    This was not unusual, the researchers said - but other experts say it could be a safety concern.

    'Long-lasting problem'
    University of Edinburgh head of psychiatry Prof Andrew McIntosh said the trial provided "the strongest evidence so far to suggest that further, larger and longer randomised trials of psychedelics are justified".

    "Psilocybin may [one day] provide a potential alternative to antidepressants that have been prescribed for decades," he added.

    But other experts point out the effects were starting to wear off after 12 weeks.

    "Depression can be a long-lasting problem and much longer follow-up periods than 12 weeks should be used," Dr Ravi Das, from University College London, said.

    A larger trial due to start soon will study how many doses are needed to prevent depression returning.

    It could be three years before the drug is close to being authorised, researchers say.
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  2. Hmmm IDK! Dosnt Sound Fun. I Like Trippin But Ion Want Headaches Nausea An Extreme Tiredness Tho I Akready Have Enough Of That Already.

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  3. My doctor (really!) told me to try LSD micro dosing and mushrooms if I ever found them. Can't find either in my neck of the woods.
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  4. Yes Iboga is very effective too, if not more effective.
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  5. Nausea was always a problem for me and kept me away. Even microdoses made me nauseous. Then, I discovered lemon tek. Cut one lemon in half. Put the juice of one half in a small bowl. Grind/smash psilocybin till most of it is a sand like texture. Some chunks are okay. I use a mortar and pestle, but anything will work. Pour the psilocybin into the lemon juice. Give it a quick stir to make sure the psilocybin is submerged and incorporated. Wait 20 minutes. Consume.

    Back to the original post:
    Ketamine clinics are starting to pop up around my area. Same idea, different drug. Great for treating trauma.
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  6. I'm seeing more research being done on DMT for major depression as well, interesting times we're living in.
  7. Sign me up.
  8. Everything is so easy to purchase right now it's crazy.
  9. #9 EmmanuelTheis, Dec 31, 2023
    Last edited: Jan 3, 2024
    The potential of using compounds from magic mushrooms to treat severe depression is a fascinating development. It's encouraging to see that such trials are exploring new avenues for mental health treatment.
    While the dreamlike state induced by psilocybin during therapy sessions seems promising, it's essential to prioritize patient safety and provide the necessary support for those undergoing treatment. The short-term side effects should indeed be carefully managed.
    Those interested in learning more about these types of therapies or exploring alternative treatments, can check out this legal lsd shop. They often provide insights into various aspects of these substances and their potential benefits.

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