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Inconclusive Drug Test

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  • Jun 03 2010 01:10 AM
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Posted 03 June 2010 - 01:10 AM

So I took a piss test a couple hours ago, and it came back "inconclusive." After doing a little research, I found out that in order for a test to come back inconclusive I would fall into one or more of these categories:

1. Tester is a heavy smoker (daily)
2. The tester took the test in the morning
3. The tester skipped breakfast
4. The tester is more than 20 pounds over weight
5. Tester used Urine LuckTM additive.
6. The lab was unable to find an adulterant

1. I haven't smoked in over a month (I was somewhat chronic before that)
2. I took the test at about 4:30 PM
3. I ate 2 eggs and cereal plus a glass of water in the morning. However, I was super hungry before going to my interview and decided not to eat right before so my breath wouldn't stink or something.
4. I'm 6' 1" and only 175 lbs so I am almost underweight.
5. Didn't mess with my piss at all
6. This is where I am a little confused. I had a cold yesterday, so I took a double dose of Nyquil Nighttime (acetaminophen, dextromethorphan, doxylamine succinate).

They sent my piss to a lab for further testing. Two questions, does anything stand out that would cause me to get an inconclusive result? and will the lab testing be able to discover that I smoked over a month ago because of more sophisticated testing?

Thanks GC
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Posted 03 June 2010 - 01:13 AM

I also just read that Dextromethorphan, when used in excess such as my double dose last night for my cold, produces similar effects as PCP, which is also tested for with standard drug tests. Not sure if that is relevant.

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Posted 03 June 2010 - 03:39 AM

I'm going to hazard a guess and say that there is no detectable amounts of THC in your urine as you have not been smoking for a month, and the lab were not testing for dextromethorphan, doxylamine succinate or acetaminophen. There is no relation to PCP. You should be safe so long as they have not taken your hair for sampling.

Edited by Neurosis, 03 June 2010 - 03:43 AM.

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Posted 03 June 2010 - 06:40 AM

I concur that they do not test for those drugs, but Dextromethorphan does have some measure of similarity (on the chemical level) to Phencyclidine that may cause it to affect drug tests:

What to do to avoid a false positive drug screen

False-positive results are possible, but highly unlikely. A false-positive result occurs when another substance in the body has a structure similar to that of one of the drugs being assayed in the screen. A few over-the-counter (OTC) medications that may sometimes lead to erroneous results include:

Vicks inhaler
Weight loss supplements


MD Consult

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Posted 03 June 2010 - 06:47 AM

I'm pretty experienced in the realm of drug tests, and I don't know if I've taken the same piss test you have, but in order for a result to come back inconclusive on the piss test I had to take, you would probably have had to had watered down piss (possibly not on purpose, but they often test for some chemical in the piss, and if it's low they figure you tried to water down the piss by drinking too much water or adding water to the sample) or you might have had a level of THC below the threshold for a positive (i think its like 20ug/l or whatever the measurement for that is, i can't remember, but it's around 20) but it still showed up. That is all I can figure, and depending on what type of test you took it could be inconclusive for different reasons, but for a traditional test (such as for probation) that's kind of how they work.

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Posted 03 June 2010 - 07:54 AM

At a glance there didn't seem to be any feasible way, as the molecules are fairly different in structure. That one anecdotal piece of evidence doesn't convince me otherwise to be honest, the guy could have been taking PCP. But I guess you can easily explain things to them if they come back pointing the finger at you for PCP abuse heh.

Anyway, this interested me to do a bit of reading into the metabolites.

DXM Metabolism:

Dextromethorphan (DM) is metabolized in the body to dextrophan (DT) and 3-methoxymorphinan (3-MM) by cytochrome P450 (CYP) 2D6 and 3A4, respectively, and cyclosporine (CsA) is a known substrate of CYP3A4

A urine metabolic ratio of dextromethorphan and 3-... [Pharmacotherapy. 1999] - PubMed result

PCP Metabolism:

These two minor dihydroxylated metabolites were:cis-4-(4′-hydroxypiperidino)-4-phenylcyclohexanol andtrans-4-(4′-hydroxypiperidino)-4-phenylcyclohexanol. The four major metabolites used in this study and their HPLC retention times were c-PPC at 3.9 min, t-PPC at 6.05 min, PCHP at 7.4 min, PCHAP at 8.6 min, and PCP at 9.5 min (see fig.1).
Posted Image

(Just as a side note, apparently one metabolite binds irreversibly to neurons... spooky shit. Glad to say I've never tried PCP).

I am hereby losing a lot of faith in the analytical world!

Edited by Neurosis, 03 June 2010 - 07:57 AM.

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