Let me explain it to you, hon. Get comfy, it takes a few paragraphs to condense the last 40 years worth of scientific studies.
Get familiar with the weird bolded
words, you will be hearing them often in the future!
It starts with the Endocannabinoid System
, the ECS
, which is made up of tiny chemical receptors (CB1s, CB2s, and GPRs
) on and between your cells. The ECS is a messaging system- your body sends messages between the cells and the whole body. The chemical message a cell receives may cause a cell to grow, die, produce a hormone, cause pain, or end it, let a memory fade, or set of the nursing reflex in an infant. If your body does it, the ECS is involved somewhere along the line!
The ECS is activated by 2-AG
. They are ENDOCANNABINOIDS,
chemicals your body makes every
moment of your life! They lift depression, keep your digestive system working properly, reduce inflammation, deaden pain, and kill cancer cells by apoptosis and autophagy, and stop the growth of feeder blood vessels to cancer which can starve it (anti-angiogenesis).
Now to our bodies, THC and CBD "look" like Ananandamide and 2-AG. Think of keys- you can have two very different looking key heads, but if the notched parts match, the key fits! That is kind of like what we have going on here- the working parts of the endocannabinoids and the phytocannabinoids
like THC and CBD can fit into the same types of CB receptor's "keyholes" and can start the needed action just like the endocannabinoids do.
Since you are asking about cancer, I'll get into what happens with cancer and the ECS.
Now when a cell "goes crazy and greedy" it becomes a cancer cell. It "forgets" that it has a certain life span and is supposed to die by a normal process called apoptosis.
Now that alone isn't too bad, but the cell also starts reproducing at a faster rate, so it (chemically) demands more blood vessels to be made to feed it's rapid reproduction rate. As more of these cells appear, the call for more food gets "louder" to the body, so new blood vessels ARE made and the "insane" colony becomes a tumor.
Now normally, the body would notice that the cell has "gone crazy" and would send it an Anadamide message that triggers a built-in message that the cell has "forgotten"- "If you are cancerous, commit apoptosis NOW
", but anandamide is fragile and is easily broken down.
Anandamide is a tiny fragile chemical message that has to float around and hit a very
small target (the CB receptor) to get the message to the bad cell. It is amazing that the ECS works as well as it does, relying on fragile messaging chemicals!
Now here's where THC (a tougher molecule) comes in!
Because it can activate the same receptors as Anandamide, THC can set off the same effects as anandamide! The CB receptor activated by THC will set off the "If you are cancerous, commit apoptosis NOW
" message, just like Anandamide.
THC and CBD mimic the chemicals in our body's own healing system! This is why cannabis does not cause cancer, but instead, heals it!
But guys, we do have one HUGE problem!!! The ECS is under attack!
This wonderful healing and regulating system is being damaged by many things! (This also cuts into your ability to get high
The ECS is in charge of getting you stoned
, as well as fighting cancer!)
So what is it that is interfering with your ECS and its ability to fight cancer (and get you stoned)? PHTHALATES
- these are softeners in plastics. You know that tacky film that slowly oozes out of your car dashboard and steering wheel? That's phthalates.
The G protein-coupled cannabinoid-1 (CB(1)) receptor of mammalian brain: Inhibition by phthalate esters in vitro. (abst - 2011) The G protein-coupled cannabinoid-1 (CB1) rece... [Neurochem Int. 2011] - PubMed - NCBI
Translation- Phthalates mess up the CB1 receptors in your brain! Messed up receptors will not work and this can cause mental (and physical) problems!
Further reading - Phthalate - Wikipedia, the free encyclopedia
LACK of OMEGA 3
- To put it simply, Omega 3 acts like a glue to stick down a tiny but important part of a CB receptor.
Cannabinoid Receptor Function is Altered by Nutritionally Deficient Diet (news – 2012) Cannabinoid Receptor Function is Altered by Nutrionally Deficient Diet - Philadelphia medical marijuana | Examiner.com
It's like having a loose wire in a speaker- the message doesn't get through!
The cancer cell may not get the "If you are cancerous, commit apoptosis NOW
" message and goes on to grow!
Keeping your ECS healthy and functioning at its best is essential! Look at what happens when they are not functioning!
[FONT="] Turned-Off Cannabinoid Receptor Turns On Colorectal Tumo
r Growth (news - 2008) Turned-off Cannabinoid Receptor Turns On Colorectal Tumor Growth
Widespread Decrease of Type 1 Cannabinoid Receptor Availability in Huntington Disease
In Vivo (full – 2010) Widespread Decrease of Type 1 Cannabinoid Receptor Availability in Huntington Disease In Vivo
(FYI- "knock-out mice" have been bred to lack certain CB receptors- they die easily, and are sickly.)
Increased Severity of Stroke
in CB1 Cannabinoid Receptor Knock-Out Mice (full - 2002)Increased Severity of Stroke in CB1 Cannabinoid Receptor Knock-Out Mice
Early onset of aging-like changes
is restricted to cognitive abilities and skin structure in Cnr1(-/-) mice. (abst – 2011) Early onset of aging-like changes is restric... [Neurobiol Aging. 2012] - PubMed - NCBI Milk intake and surviva
l in newborn cannabinoid CB1 receptor knockout mice: evidence for a "CB3" receptor. (abst – 2003) Milk intake and survival in newborn cannabin... [Eur J Pharmacol. 2003] - PubMed - NCBI
Loss of Cannabinoid Receptor CB1 Induces Preterm Birth
(full - 2008) Loss of Cannabinoid Receptor CB1 Induces Preterm Birth
Deficiency of type 1 cannabinoid receptors worsens acute heart failure
induced by pressure overload in mice. (abst – 2011) Deficiency of type 1 cannabinoid receptors worse... [Eur Heart J. 2011] - PubMed - NCBI
You let yourself open to all that and more if your ECS is damaged! Take your Omega 3, eat a healthy diet, and avoid plastic (or at least wipe it clean now and then).
And I think that covers it!
Edited by Storm Crow, 26 May 2012 - 07:25 PM.