Hahaha, itll make you tired. BUt like johnny said, weed mixeswith EVERYTHING. Ive done weed and meth, weed and coke, weed and heroin, weed and thizz, weed and crack, weed and acid, weed and shrooms, weed and painkillers, weed and xanax, weed and liquor, even weed and pcp (smoked a 'wet' joint).