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weed and dopamine

Discussion in 'Marijuana Consumption Q&A' started by DoctorReefer, Mar 16, 2013.

  1. #1 DoctorReefer, Mar 16, 2013
    Last edited by a moderator: Mar 16, 2013
    okay so it has been shown that THC releases dopamine in the striatum. It doesn't release as much dopamine as other drugs like E though right? that explains why you don't feel like shit the day after smoking a bunch of ganja. but you do feel burnt-out after smoking a bunch of weed? is this why? also,

    This led me to a theory that is not backed by any facts other than the idea that dopamine is indeed released in the brain from marijuana. Marijuana, when taken in small doses throughout the day can act as an excellent anti-depressant, but when smoked in copious amounts( a sesh or really anything big enough to make you burn-out after) will have the opposite effect.

    anybody wanna weigh in?
     
  2. #2 DoctorReefer, Mar 16, 2013
    what do the dopamine/ seratonin levels, and actually the brain chemistry in general of a marijuana smoker look like compared to a non-smoker?
     
  3. #3 OneLoveMaryJane, Mar 16, 2013
    Last edited by a moderator: Mar 16, 2013
    Weed releases dopamine indirectly via cannabinoid antagonization. Since it's indirect it can't reek havok on dopamine since the cannabinoid receptors turn off as a mediator. That particular unmentionable releases a shitload of serotonin and that's why you feel like shit the next day, it straight up antagonizes serotonin so much that a good amount of the receptors shut off, and it's fairly toxic so it straight up destroys a few of the neurons as well, causing more long term depression. It does antagonize dopamine a lot more than weed since it does it directly and it is an amphetamine, but not nearly as much as serotonin which is the real cause of the depression the next day.


    Try taking 5htp the next day if you want to avoid the shitty feeling. It's the precursor to serotonin so your body can produce more.
     
  4. #4 OneLoveMaryJane, Mar 16, 2013

    It would depend on how much you smoke, nothing drastic though.
     
  5. #5 DoctorReefer, Mar 16, 2013
    thanks.
     
  6. #6 FrostyPurpleNug, Mar 16, 2013
    Idk, you're the doctor ;)
     
  7. #7 DoctorReefer, Mar 16, 2013
    yeah i'm just checking in with my colleague one love here, hes a neurologist. let the smart people discuss please.
     
  8. #8 Ponyboii2, Mar 16, 2013
    Idk I agree with your theory. Just from experience if u take a couple hits I feel great with little to no burnout/sluggishness afterwards. Compared to sessions where it's multiple bowls, or fat blunt..I feel good for a while but when I start coming down I just feel really tired for a good while after blazing. Ima try to cut my intake and basically use the herb 'better' I guess you could say. But I'll always love gettin blowed once in a while despite the somewhat negative effects afterwords.
     
  9. #9 bluekangaroo, Mar 16, 2013
    As long as you smoke in moderation, you should probably be fine. If you feel sluggish, then I have a weird tip that will make your dopamine levels/'reserves' constantly high.
     
  10. #10 Leoo617, Mar 16, 2013

    What is it?
     
  11. #11 bluekangaroo, Mar 23, 2013
    This may sound weird, but stop masterbating, try it for like a week. See,when you masterbate, you release large amounts of dopamine, if you refrain, however, it'll build up again. By the end of that week, you'll be really energetic. Sorry about the bump
     
  12. #12 tokteza, Mar 23, 2013

    haha back in high school a week before state track meet are coach would have "the talk" with us idk if it really helped alot but I always thought it did.
     
  13. #13 OneOfTheGoodOnes, Mar 24, 2013
    I thought they were the same.
    Wait, they are the same!
     
  14. #14 Tokerton, Mar 24, 2013
    Slow down, Doc. I thought weed and ganja were the same thing.
     
  15. #15 TeHNeutral, Mar 24, 2013

    First time in my life, time to take a tolerance break with ejaculation.
     
  16. #16 DoctorReefer, Mar 24, 2013
    I don't think you guys read that the way I intended it to be read.
    Ganja is the same thing as weed, but being burnt out and feeling like shit the day AFTER smoking are two separate things entirely.
     
  17. #17 FaMiLytilIdie, Mar 24, 2013

    5 htp helps a lot. And @OP I wouldn't so much call it a "burned out" feeling as much as a pleasant afterglow haha.
     
  18. #18 DoctorReefer, Mar 24, 2013

    Yeah but it can make me tired which isn't plesent, especially when I smoke in the mourning, or during the day. That's why you should smoke small bowls according to my theory.
     

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