Understanding stomach diseases and marijuana

Do you drink alcohol at all?Sent from my iPhone using Grasscity Forum

 

Here's the section my List on pancreatitis-  some may be helpful, but others, like the ones on genetics, won't help you much.
 
Pancreatitis & Medical Marijuana         (article - undated)   http://onlinepot.org/medical/pancreatitis.htm
 
The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis.     (full - 2005)      https://www.jstage.jst.go.jp/article/tjem/207/2/207_2_99/_pdf
 
Gpr40 Gene Expression in Human Pancreas and Insulinoma.       (abst – 2005)
http://www.ncbi.nlm.nih.gov/pubmed/16289108
 
Expression of the Gene for a Membrane-bound Fatty Acid Receptor in the Pancreas and Islet Cell Tumours in Humans: Evidence for Gpr40 Expression in Pancreatic Beta Cells and Implications for Insulin Secretion.         (abst – 2006)
http://www.ncbi.nlm.nih.gov/pubmed/16525841
 
Cannabinoids ameliorate pain and reduce disease pathology in cerulein -induced acute pancreatitis        (full - 2007)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268094/?tool=pubmed
 
Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects        (abst – 2008)       http://gut.bmj.com/content/57/8/1140.abstract
 
Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells       (full - 2008)    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2253501&rendertype=abstract
 
Expression and function of cannabinoid receptors in mouse islets.        (full – 2010)
http://www.landesbioscience.com/journals/islets/LiISLETS2-5.pdf
 
Cannabinoid receptors are coupled to stimulation of insulin secretion from mouse MIN6 beta-cells.        (full – 2010)   http://content.karger.com/produktedb/produkte.asp?DOI=000320527&typ=pdf
 
G1359A polymorphism of the cannabinoid receptor gene (CNR1) and clinical results of biliopancreatic diversion             (link to PDF – 2010)       http://www.europeanreview.org/article/724
 
The role of small molecule GPR119 agonist, AS1535907, in glucose-stimulated insulin secretion and pancreatic β-cell function         (abst  â€“ 2010)  http://www.ncbi.nlm.nih.gov/pubmed/21114601
 
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells.      (full – 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21346174
 
Gut feelings about the endocannabinoid system       (full – 2011)
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2011.01689.x/full
 
 The role of the endocannabinoid system in islet biology.       (abst – 2011)
http://www.ncbi.nlm.nih.gov/pubmed/21311323
 
Effects of CP 55,940--agonist of CB1 cannabinoid receptors on ghrelin and somatostatin producing cells in the rat pancreas.           (full – 2012)  http://czasopisma.viamedica.pl/fhc/article/view/18705/14714
 
Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis.         (full - 2012)    (HU210 acts like THC, activating both CB1 and CB2 receptors)
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
 
Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol          (link to PDF - 2012)
http://www.scirp.org/journal/PaperInformation.aspx?paperID=17302
 
Cannabis exposure associated with weight reduction and β-cell protection in an obese rat model.      (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22421529
 
Activation of Cannabinoid Receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms.  
(abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/23139224
 
Cannabinoid HU210 Protects Isolated Rat Stomach against Impairment Caused by Serum of Rats with Experimental Acute Pancreatitis             (full – 2013) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0052921
 
Cannabis Care: Manchester grandmother fears getting caught for using marijuana, waits anxiously for bill to pass              (news – 2013)    
http://www.nashuatelegraph.com/news/1011730-469/story.html
 
Getting a vaporizer is a good idea. You might also look into tinctures and edibles. I'd start here for recipes-
 
BadKat's CannaPharm: Canna Caps, UV Reactive GLOWING Hash Candy, Canna 'Bombs' & more       (forum post - 2011)   
http://forum.grasscity.com/incredible-edible-herb/742831-badkats-cannapharm-canna-caps-uv-reactive-glowing-hash-candy-canna-bombs-more.html
 
Hon, PM me your email and I will send you off a copy of my List ASAP, then you will have all the research at your fingertips! 
 
Granny
 
ps- what your body is doing sounds a lot like what happens when I get benzoate of soda/sodium benzoate in my system! It's a food additive that my body says it is pure poison, but most folks eat it without any problems!   

 

I think it unlikely, but everyone's body is different- like me and benzoate of soda! The cannabinoids themselves are enough like our own endocannabinoids that they rarely cause problems. But there are a few studies that claim cannabis as a cause of pancreatitis, like this one-  
 
Cannabis: a rare cause of acute pancreatitis. http://www.ncbi.nlm.nih.gov/pubmed/22749694
 
However, I want you to consider how many folks use cannabis, and that in the last decade there have been just 7 reports of this- less than one a year.  As the title says, a rare cause, but it is not impossible.  (Kids, NOTHING is 100% good, all the time- not even cannabis!)
 
The act of smoking, however, is definitely "iffy"- you get too much CO2, Carbon monoxide, and other combustion products which can throw your body out of kilter. I would get the vaporizer. Avoid the really cheap ones- I have seen reports of increased chemical sensitivity and lung problems from the "Made in China" cheapies!  Get a name brand, preferably one made in the USA.
 
 
Granny

 

I think most of the Crohn's patients on the board are into edibles rather than smoking or vaping though there is nothing stopping any one from doing both if they want to.  You shouldn't need to look far back in list history to find a few Crohn's threads and other patients who can help you with that.part of your problem.  It is delicate business for some of us trying to treat inflammatory conditions.  I have asthma.  If I smoke or vape MMJ makes my asthma worse, Lots of asthma patients here have very good results smoking their medicine. The only way it works for me is when I stick to tinctures' infused oils and topical MMJ.  Using MMJ that way makes my asthma better to the point that I've been off the "Traditional? Pharmaceuticals" that treat asthma and arthritis for more than 2 years now. 
 
Be careful of steroids.  They told me it wouldn't cause osteoporosis but here I am a guy in his 50's and I have osteoporosis now.  In case you don't know that is kind of young for a guy.

 

You should look into traveling to see a knowledgable doctor.  Your CD might not be bad now but its a progressive disease, and without treatment it will continue to get worse.  With a doctor who understands your condition you can stop the progression of the disease now and use diet and medications to maintain remission.
 
I agree with Honokiol as well, if you can edibles can be great help for stomach problems.  If you can get access (I have no idea what SD is like but I doubt it's a real heady community), you might also consider buying or making your own Cannabis Oil (either with butane or ethanol).  I find vaping BHO is the most effective spur-of-the-moment medicine I have for stomach issues, and I've read amazing things about ethanol-extracted Cannabis Oil (similar to Rick Simpson Oil), for the treatment of Crohn's (using a regiment similar, but smaller, to cancer treatment, as CD is autoimmune, and then staying on a maintenance dose to stay healthy).  I know of a dispensary/hotel in Oregon that have a program set up to bring in patients from around the country to stay in their hotel for 60 days while they receive their oil treatment--all for less than a round of chemo.
 
But most important is seeing a doctor who is knowledgable about IBD and getting an understanding of what's happening right now.
 
(and since you didn't mention having one, I'll reassure you, colonoscopies aren't that bad--the prep is gross but you go in and then you get a nice drug nap and you wake up like nothing happened--I'm 24 and I've had 4)

 

I was awake and watching the Tv with the doc for my last colonoscopy.  Well medicated but awake.  (Cancer watch I'm at risk X2)
 
Be careful of any one who wants to put you on steroids for any thing.  I was on them for asthma since the 1980's mostly inhaled and now have osteoporosis.  They are bad news and most of the research suggests that most of the damage is done in the first few doses.
 
I use cannabis as a replacement for inhaled corticosteroid therapy in the treatment of asthma due to the inadvisability of such therapy in the presence of osteoporosis as well as for other medical purposes.
 
- Edit -
 
P.S.
Cannabis is providing better asthma control than the inhaled corticosteroid therapy it replaced.

 

You think pancreatitis sucks? Search the research for cannabis related to increased odds of schizophrenia. Its all scary until you do the math. Say most are at .3% chance(hypothetical), but you got scared cause you see that MJ makes you 17 times. (also a made up statistic . This is an actual study, but I'm too lazy to look for it and link)
 
What people forget is that your percentage for getting it in the first place was .3
.3 x 17 is like 5% so when you thought there  was a crazy high number chance to get the specific ailment, you freak out, but what what looked like a possible huge risk, still remains miniscule when weighing it against the medical benefits for a lot of people.
 
Now that part had nothing to do with the first persons post, but as general information.
 
For the first poster, vaporizing or smoking can cause irritation in the stomach, especially to those that take in huge hits and hold it as long as possible. They end up swallowing some cloud and for some, can be enough to cause indigestion, heartburn, stomach cramps, aches, diarrhea, depending on how often you swallow smoke into your body. I know this after my own long research on having extreme pains. I stopped taking drinks while I had hits held in and taking swallows. It didn't go away completely, but it did make it a ton better.
 
I do suffer from ptsd, my stomach problems came from that, but was made worse with the above mentioned. It took a month or so for my stomach to stop the crazy hunger pains when I wasn't hungry. I did everything up to keeping food on me. Did not help. If you smoke, switch to vape and try not chasing clouds. Also, don't hold the vapor in too deep. Try smaller amounts like the size of a solo bowl too. If you're already doing all this and it hasn't helped, hope you find something as I know what its like to have a feeling of knives in your guts.
 
Anyways, smoke in your guts would be irritating to say the least, possibly causing muscle spasms, cramps and all the other stuff that hurts.

 

What if that's a correlational relationship but not causal?  Say, for those with budding schizophrenic symptoms cannabis makes them more comfortable in their own skin, so they continue.  Later they develop into full-blown schizophrenia, through no causal effect of the cannabis, simply because they were using it to help with schizophrenia-related symptoms (the same reason most schizophrenics smoke cigarettes, they report it lessens their symptoms).
I'm not saying this is the case, but last I heard those schizophrenia studies were on pretty shaky ground...

 

The exact details on the actual study is on google somewhere or in one of my past post if you'd like more info. I was only using it as a reference for just some of the things that have studies going on with cannabis and that it can have negative effects as well as positive like everything else. Nothing is a cure all, but that doesn't mean that the raw percentages you see should scare you.
 
As this wasn't a post about schizophrenia, I wasn't using any actual studies or factual evidence.

 

i read somewhere that weed has 20 times the anti inflammatory effect as Tylenol So smoking a bowl would be like taking 20 Advil or something. (Taking 20 Advil would severely damage your stomach)

 

 
Tylenol gets it's action by inhibiting cannabinoid uptake. Dont worry you can get it in the abstract.

Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826109/

 

 
My point exactly.  The OP has a serious illness and it's widely recognized among sufferers that cannabis is one of the best, if not THE best medicine for Crohn's symptoms, so he doesn't really need your off-topic non-help.

 

Wow, ok. First, thanks for YOUR opinion on MY opinion which helped so much more than the main part of my post of smoke being a cause of his symptoms (as someone that has been tested for crowns). What a helpful fellow you have been providing any insight to any symptoms or possible causes that may not be related to crohns its self. Now you may want to re read his post and see he wasn't talking about having that as his current illness so we are not even talking about crohns on this thread and my statement on schizophrenia was meant as anecdotal at best as a way to look at odds of anything causing anything in relation to their actual odds.
 
Now go eat a brownie or something, cheer the hell up and stop bein a dick.

 

Cannabis is an awesome medicine, vitamin C is as well. Here is some information on vitamin C, one doctor has used it to treat pancreatitis.