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Discussion in 'General' started by #vapenation, Feb 26, 2014.

  1. Below is a document I have put together from medicalmarijuana.com and would like to hear your input. Marijuana has changed my life and helps me day to day to live with the pain I am in. I'm not asking for you to read the entire thing ( it is 9931 words), but at least read the first paragraph that i have written to get a general idea of my situation and I would appreciate some input. Sooner or later I am going to show this to my parents… When the time is right. I'm 18 and too young to be dealing with this. Believe it or not, it is true.
     
     
     
    I smoke Marijuana. I tend to think of it as self medicating. Why? Because I live day to day in pain. Every day I wake up with pain in my back, my ankle, and my stomach. I do not self medicate every day, but when I do the pain is gone, I am more focused, and all the stress I have is lifted off my shoulder. I do not smoke to get “high”. I smoke to help with my pain. The headaches I randomly have don't happen if I smoke a couple times a week. When I got caught I did not smoke for months. A few weeks after I stopped the pain was getting worse and worse. I was in the hospital at least once a week a month after I stopped because the pain in my stomach was unbearable. To this day, Feb 25, 2014,  I have received no answers to what the stomach pain is coming from. They save I have inflammation in part of my colon but there have been no diagnoses'. The foot pain, I have broken my ankle in the same place four times and have never fully recovered. I have had random headaches every few days since the 2<sup>nd</sup> grade with no answers to what is causing them. I believe it is because of the fluorescent lighting in school. In the past year I have had countless x-rays, three MRI's, two CAT scans, an ultrasound, and a colonoscopy. None of them gave me answers to what is causing the pain I live in. In January I decided I had enough of the pain and started smoking again. The pain is now manageable. It is still present but not nearly the intensity it was a few months ago. Below is a list of what I suffer from and a few things that could be the problem with my stomach…
     
     
     
     
     
     
     
    [SIZE=18pt]Chronic Pain: What is the definition?[/SIZE]
    Taken from an online Medical Dictionary: Pain (an unpleasant sense of discomfort) that persists or progresses over a long period. In contrast to acute pain that arises suddenly in response to a specific injury and is usually treatable, chronic pain persists over time and is often resistant to medical treatments.
    Chronic pain is a discomfort that gradually increases over a period of time and eventually becomes a consistent pain and is often unaffected by medical treatments. Acute pain is just the opposite. It occurs because of an accident or injury and is treatable. There are different causes for chronic pain: back injury, arthritis, carpal tunnel syndrome, fibromyalgia, osteoporosis, scoliosis and multiple sclerosis are just a few of the conditions that can lead to chronic pain.  
    [SIZE=18pt]There's a Better Way[/SIZE]
    Unfortunately, until recently, the United States government has had outdated views on marijuana. Classed a Schedule I drug, it has been illegal and considered a dangerous drug with no medical value. However, views are slowly beginning to change. Medical Marijuana is beneficial in the treatment of chronic pain. In addition to its analgesic effects, cannabis has anti-inflammatory properties as well. It can work very well as an adjunct to other medications. Although opioid medications are effective in treating the pain in the beginning, over time, a tolerance can develop causing the patient to take more and more. Research has shown that except for the potential damage to the lungs, cannabis is safer than many of the legal drugs used for pain. There is no known case of legal overdose with cannabis. Not only can marijuana effectively treat pain, it can also treat the nausea associated with opioid medications. Unlike Marinol (synthetic THC), inhaled marijuana offers immediate relief because it is absorbed right into the bloodstream. It also contains quite a few other cannabinoids like CBC and CBD. Marinol is synthetic THC only. Marinol is just not as effective as medical marijuana.
    Chronic pain has reached epidemic proportions in this country. Chronic pain is often defined as pain that lasts three months or longer. Although it is more common in older adults, anyone can experience it. Approximately 50 million people suffer from chronic pain, and another 25 million suffer from acute pain caused by surgery and accidents.
    One of the main problems with chronic pain is that it is usually under treated. According to the National Chronic Pain Outreach Association, seven million people are unable to relieve their pain without taking opioids. Many doctors, for many different reasons, will not prescribe an adequate dosage to combat their patient's pain. Tragically, living with intractable pain can lead to depression. Depression can lead to suicide.
    [SIZE=14pt]"Severe chronic pain is usually treated with opioid narcotics and various synthetic analgesics, but these drugs have many limitations."[/SIZE]
    Opioids are addictive and tolerance develops. The most commonly used synthetic analgesics - aspirin, acetaminophen (Tylenol), and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen -are not addictive but they are often insufficiently powerful. Furthermore, they have serious toxic side effects including gastric bleeding or ulcer and in the end a risk of liver or kidney disease. Stomach bleeding and ulcers induced by aspirin and other NSAIDs is the most common serious adverse drug reactions reported in the United States. These drugs may be responsible for as many as 76,000 hospitalizations and more than 7,600 deaths annually.
    Acetaminophen is increasingly prescribed instead because it largely spares the digestive tract, but it can cause liver damage or kidney failure when used regularly for long periods. Medical researchers have estimated that patients who take one to three acetaminophen tablets a day for a year or more account for about 8% to 10% of all cases of end-stage renal disease, a condition that is fatal without dialysis or a kidney transplant. 
    Given the limitations of opioids and non-addictive synthetic analgesics, one might have expected pain specialists to take a second look at cannabis, but the medical literature again suggests little recent reconsideration.  Medical Cannabis may be especially useful for the kinds of chronic pain that people who survive catastrophic traumatic accidents have to live with the rest of their lives.
    Take side effects, for instance. Most prescription drugs come with a multi-page rider of possible bad things that might happen with regular use – liver damage is synonymous with long-term use. Baked goods, butters, oils, suppositories, tinctures and salves are all ways to get the medication into your system easily.
The number one benefit of marijuana: it is natural. It is not processed, refined, or chemically enhanced. It does not contain an endless list of unpronounceable ingredients. It is naturally pure. . .
    Many patients are unaware that there is a safer and more effective way to treat chronic pain. Cannabis (marijuana) contains medical compounds called cannabinoids.  Scientists have identified cannabis receptors in the human body that are located in the central nervous system (brain and spinal cord) and the peripheral nervous system as well (the nerves that innervate muscles and organs). This means that when inhaled they bind to the nerves that regulate pain throughout the body and “block” or dampen the body's response to pain. The amazing thing about these cannabinoids is that they have a safety profile that is unprecedented in medicine. There has never been a documented overdose from cannabis. In addition, the potential for addiction is very small.  Most patients who have trouble controlling their use have other drug addictions. Cannabis almost immediately relieves pain and eliminates the nausea that many patients experience... Many elderly patients have a difficult time healing because they are not getting the necessary nutrition that they need. Patients can medicate throughout the day without the fear of taking opiates.  One of the other side effects is that cannabis will stimulate a patient's appetite. This is a positive effect for the elderly. 
     
     
    Back Pain
     
    Chronic Back Pain is one of the most common illnesses seen by physicians.  Almost everyone has back pain at some time in their adult life.  Back pain occurs most commonly between the ages of 30 and 50 due to the aging process and due to a more sedentary lifestyle that begins in this age group.  The pain can be neuropathic or nociceptive.  Neuropathic pain is caused by damage to a nerve.  This kind of pain is felt as a sharp stabbing or burning.  Nociceptive pain is caused by disease to the tissues outside of the nerves.  It is felt as a dull ache or sense of pressure. Examples of these kinds of pain are a pinched nerve (neuropathic pain), and arthritis (nociceptive pain).  It is frequent for patients to have both types of pain at once, called mixed pain.
    Fifty percent of patients with back pain have experienced some type of trauma, such as a sports injury or motor vehicle accident. But the other fifty percent have no known cause of their back pain.  Most patients who seek care for their back pain will undergo some type of evaluation that may include x-rays, CT scan, and/or MRI; occasionally some patients will have a myelogram (dye injected into the spinal cord area followed by x-rays) or bone scan (dye injected into the blood which will then concentrate in an abnormal area of bone).  Many times no obvious cause of the pain is found.
    Patients who have acute back pain will often improve or recover in six to eight weeks.  Patients with acute pain occurring more than three times in one year or who experience longer episodes of back pain that interfere with daily activities (e.g., sleeping, sitting, standing, walking, bending, riding in or driving a car) are more likely to develop a chronic back condition.  Sometimes these chronic back pain patients will have pain, numbness or tingling in their legs.  Some patients with chronic pain do not respond to conventional therapy and have to find a way to live with their pain.  Physicians have found that living with chronic pain is extremely difficult and can lead to opioid dependency (addiction), anxiety, depression, and insomnia.
    [SIZE=18pt]The Treatment of Choice[/SIZE]
    Medical marijuana is increasingly becoming the treatment of choice for many chronic back pain patients.  Conventional treatment therapies such as over the counter non-steroidal anti-inflammatory medications – NSAIDS – (such as ibuprofen, naproxen sodium, or aspirin) can be helpful but can cause side effects such as stomach upset, nausea, gastric bleeding, and ulcers.  Prescription medications like other NSAIDS (like Celebrex) or opiates (like Vicodin or Norco) can be effective at treating pain but can also cause many adverse and unacceptable side effects.  The addictive potential of opiates is very concerning to patients who struggle with chronic pain and need relief; it is this concern that leads patients to consider using medical marijuana, a very effective treatment for chronic back pain.
    In 1975, scientists began studying THC in cancer patients and found that it was a very effective pain reliever without significant or toxic side effects.  Other studies followed and the conclusion was the same: marijuana safely and effectively treats chronic pain with little to no side effects.  No nausea, no stomach upset, no ulcers, no addiction – many patients jokingly only refer to an increased appetite (”munchies”) the only “bad” side effect.  Marijuana side effects of elevated mood, improved sleep, and reduced anxiety are welcomed by most patients and considered beneficial to having a good quality of life when you suffer daily with chronic pain.
    [SIZE=18pt]How can medical marijuana help your chronic back pain?[/SIZE]
    •    You will reduce or eliminate pain, allowing you to continue being active
    •    You will reduce or eliminate the use of potentially addictive medications or dangerous medication side effects
    •    You will reduce or eliminate the anxiety, depression, and insomnia associated with chronic pain
    •    You will feel better knowing that you are using a natural treatment for the pain
    •    You will have better quality of life
    •   
    [SIZE=18pt]Evidence for Medical Marijuana[/SIZE]
    In 1999, the Institute of Medicine (IOM) issued an evidence-based report on medical marijuana. It listed conditions that may be helped by cannabinoids, including neuropathic pain, acute pain, spinal cord injury, post operative pain, cancer pain, multiple sclerosis, nausea and appetite control among others.
    The report says that discovery of a cannabinoid receptor in the parts of the nervous system that detect and control pain perception means that marijuana is a very promising source of pain relieving medications in the future.
    The IOM found that cannabinoids are capable of giving mild to moderate pain relief comparable to codeine. In one study cited in the report, 10 milligrams of THC (marijuana's active ingredient) yielded the same amount of pain relief as 60 milligrams of codeine. Side effects were similar with both drugs, but the THC seemed to be more sedating than the codeine. The patients taking the THC reported a greater sense of well-being and less anxiety.
    The IOM also found that by combining cannabinoids with an opioid, the opioid may work better. This may decrease the dose of addictive narcotics needed to control pain.
     
     
     
    ADD
     
    Individuals with attention deficit disorder have problems with self-regulation and self-motivation because they get distracted, or procrastinate, or lack organizational skills or the ability to prioritize.  It is a chronic condition beginning in early childhood.  ADHD is a condition in which the brain cannot ignore unimportant stimuli.
    Current research shows that certain strains of medical marijuana can allow the patient to “focus” on their project.  Marijuana was used as a replacement for other medications (Ritalin or Methylphenidate).  Chronic symptoms of ADHD are improved with the use of medical marijuana.
    [SIZE=18pt]Chronic Symptoms:[/SIZE]
    •    Hyper-impulsivity (restless, agitation, RLS (restless leg syndrome)-THC binds to the CB1 receptors to modulate and decrease neuronal activity.  Thus providing a calming effect.
    •    Anxiety-CBD binds to CB2 cannabinoid receptors.  CBD is an anti-anxiety agent.  CBD also reduces THC's psychoactive (adverse) effects.
    •    Panic Attacks-THC helps to decondition CB1 receptors.
    •    Hyper sensibility to stressful situations-THC/CBD act to relieve anxiety and fear.
    •    Lack of attention-THC slows the ADHD brain's over activity so patient can remain focused on project at hand.
    •    Insomnia-THC slows the brain
    •    Depressive tendency-THC binds to CB1 receptors to allow serotonin release.
    •    Alcoholism tendency-cannabis as a substitute.
    •    Tics-THC proven treatment for Tourette's syndrome.
    •    OCD (obsessive-compulsive disorder)-personality disorder
    •    PTSD (posttraumatic stress disorder), mood disorders,  all helped with cannabis.
    •    Sexual hyperactivity- cannabis to treat successfully.
    Gaming mania-cannabis to treat successfully.
     
     
    Headaches
     
    Migraine headaches can be extremely severe and debilitating. Scientists and doctors are not sure exactly why some people get migraines but it appears that genetics and environmental factors both play a role.  About 15% of the population suffer with migraines. They are more common in women.  About 80% of people who have migraines have a family member who also has migraines.
    Migraines are possibly caused by changes in the trigeminal nerve, a major pain pathway. Imbalances in brain chemicals also may be the culprit.  One of our neurotransmitters, serotonin - which helps regulate pain in the nervous system - also may be involved.
    There are a number of factors that can be the starting cause of migraines;  these are called triggers.  Some well known triggers for migraines are hormonal changes (menstruation, menopause, pregnancy), certain foods (MSG, chocolate, cheese, nuts, alcohol), missing a meal, change in weather, or very commonly, stress.
    About 20% of migraine sufferers have an aura (usually a visual disturbance) before the onset of pain.  More often there is just the onset of pain which becomes severe and debilitating.  Although migraine pain usually appears on one side of the head, 30-40% of migraineurs have them on both sides.  One can have nausea, vomiting, light-sensitivity and sound sensitivity.  Migraines can last anywhere from 4 hours to 3 days.
    Many of the medications currently used for migraine headaches have significant side effects and often do not prevent or relieve all of the symptoms. Marijuana was used to treat migraine headaches for many years in the nineteenth century, however due to the political climate and attitude towards marijuana in the twentieth century, it was not researched or promoted as an effective treatment for migraines. Many people who suffer from migraines found on their own that marijuana either prevented or lessened the intolerable pain from this condition.  Recent research has shown that THC, the active ingredient in marijuana, inhibits the release of serotonin from the blood of migraine sufferers during an acute attack, thereby reducing symptoms of pain.
    Although further scientific research is needed, many patients are using medical marijuana safely and effectively to prevent and treat their migraine headaches.  Many patients have found that they no longer need prescription medications with adverse side effects in order to treat their migraines.  Others have found that the other benefits of medical marijuana, like improved sleep and less stress and anxiety, reduce the frequency of their migraines.  Overall, medical marijuana patients who have migraine headaches find that their quality of life is improved with this treatment.
     
     
    IBS
     
     
    What does the colon do?
The colon, which is about five feet long, connects the small intestine to the rectum and anus. The major function of the colon is to absorb water, nutrients, and salts from the partially digested food that enters from the small intestine.  Two pints of liquid matter enter the colon from the small intestine each day.  Stool volume is a third of a pint. The difference between the amount of fluid entering the colon from the small intestine and the amount of stool in the colon is what the colon absorbs each day.
Colon motility-the contraction of the colon muscles and the movement of its contents-is controlled by nerves, hormones, and impulses in the colon muscles.  These contractions move the contents inside the colon toward the rectum.  During this passage, water and nutrients are absorbed into the body, and what is left over is stool.  A few times each day contractions push the stool down the colon, resulting in a bowel movement.  However, if the muscles of the colon, sphincters, and pelvis do not contract in the right way, the contents inside the colon do not move correctly, resulting in abdominal pain, cramps, constipation, a sense of incomplete stool movement, or diarrhea.
As its name indicates, IBS is a syndrome-a combination of signs and symptoms.  IBS has not been shown to lead to a serious disease, including cancer.  Through the years, IBS has been called by many names, among them colitis, mucous colitis, spastic colon, or spastic bowel.  However, no link has been established between IBS and inflammatory bowel diseases such as Crohn's disease or ulcerative colitis.
There are many possible causes of IBS.  For example, there may be a problem with muscles in the intestine, or the intestine may be more sensitive to stretching or movement.  There is no problem with the structure of the intestine.
It is not clear why patients develop IBS, but in some instances, it occurs after an intestinal infection.  It is called post-infectious IBS.  There may also be other triggers.
Stress can worsen IBS.  The colon is  connected to the brain through nerves of the autonomic nervous system.  These nerves become more active during times of stress, and can cause the intestines to squeeze or contract more.  People with IBS may have a colon that is over-responsive to these nerves.
IBS can occur at any age, but it often begins in adolescence or early adulthood.  It is more common in women.  About one in six people in the U.S. have symptoms of IBS.  It is the most common intestinal complaint for which patients are referred to a gastroenterologist.
Symptoms range from mild to severe.  Most people have mild symptoms.  Symptoms vary from person  to person.
Abdominal pain, fullness, gas, and bloating that have been present for at least six  months are the main symptoms of IBS.  The pain and other symptoms will often:
• Occur after meals
• Come and go
• Be reduced or go away after a bowel movement
People with IBS may switch between constipation and diarrhea, or mostly have one or the other.
• People with diarrhea will have frequent, loose, watery stools.  They will often have an urgent need to have a bowel movement, which is difficult to control.
• Those with constipation will have difficulty passing stool, as well as less frequent bowel movements.  They will often need to strain and will feel cramping with a bowel movement.  Often, they do not eliminate any stool, or only a small amount.
For some people, the symptoms may get worse for a few weeks or a month, and then decrease for a while. For other people, symptoms are present most of the time and may even slowly increase.
Irritable bowel syndrome is most likely a lifelong condition.  For some people, symptoms are disabling and reduce the ability to work, travel, and attend social events.  Symptoms can often be improved or relieved through treatment.
    
Symptoms include
• Abdominal pain or discomfort for at least 12 weeks out of the previous 12 months.  These 12 weeks do not have to be consecutive.
• The abdominal pain or discomfort has two of the following three features:
1. It is relieved by having a bowel movement.
2. When it starts, a change occurs in how often a person has a bowel movement.
3. When it starts, a change occurs in the form of the stool or the way it looks.
Certain symptoms must also be present, such as:
– a change in frequency of bowel movements
– a change in appearance of bowel movements
– feelings of uncontrollable urgency to have a bowel movement
– difficulty or inability to pass stool
– mucus in the stool
– – bloating
    
Bleeding, fever, weight loss, and persistent severe pain are not symptoms of IBS and may indicate other problems such as inflammation or, rarely, cancer.
The following have been associated with a worsening of IBS symptoms:
• large meals
• bloating from gas in the colon
• medicines
• wheat, rye, barley, chocolate, milk products, or alcohol
• drinks with caffeine, such as coffee, tea, or colas
• stress, conflict, or emotional upsets
    
Researchers have found that women with IBS may have more symptoms during their menstrual periods, suggesting that reproductive hormones can worsen IBS problems.  In addition, people with IBS frequently suffer from depression and anxiety, which can worsen symptoms. Similarly, the symptoms associated with IBS can cause a person to feel depressed and anxious.  Symtoms range from mild to severe.  Most people have mild symptoms.  Symptoms vary from person to person.  People with IBS may also lose their appetite.
Irritable bowel syndrome (IBS, or spastic colon) is a diagnosis of exclusion.  It is a functional bowel disorder characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause.  In some cases, the symptoms are  relieved by bowel movements.  Diarrhea or constipation may predominate, or they may alternate (classified as IBS-D, IBS-C or IBS-A, respectively).  IBS may begin after an infection (post-infectious, IBS-PI), a stressful life event, or onset of maturity without any other medical indicators.  Although there is no cure for IBS, there are treatments that attempt to relieve symptoms, including dietary adjustments, medication and psychological interventions.  Patient education and a good doctor-patient relationship are also important.
Several conditions may present as IBS including celiac disease, fructose malabsorption,  mild infections, parasitic infections  (like giardiasis),  several inflammatory bowel diseases, bile acid malabsorption, functional chronic constipation, and chronic functional abdominal pain.  In IBS, routine clinical tests yield no abnormalities, although the bowels may be more sensitive to certain stimuli, such as balloon insufflating  testing.  The exact cause of IBS is unknown.  The most common theory is that IBS is a disorder of the interaction between the brain and the gastrointestinal tract (brain-gut),   although there may also be abnormalities in the gut flora or the immune system. 
    IBS does not lead to more serious conditions in most patients.   However, it is a source of chronic pain, fatigue, and other symptoms and contributes to work absenteeism.   Researchers have reported that the high prevalence of IBS,  in conjunction with increased costs, produces a disease with a high social cost.   It is also regarded as a chronic illness and can dramatically affect the quality of a sufferer's life.
    
Causes
The cause of IBS is unknown, but several hypotheses have been proposed.  T he risk of developing IBS increases six -fold after acute gastrointestinal infection.  Post-infection, further risk factors are young age, prolonged fever, anxiety, and depression.  Publications suggesting the role of  “ brain-gut “  association appeared in the 1990s, such as a study entitled  "Brain-gut"  response to stress and cholinergic stimulation in IBS published in the Journal of Clinical Gastroenterology in 1993.   A 1997 study published in Gut magazine suggested that IBS was associated with a "derailing of the brain-gut axis."   Psychological factors may be important in the etiology of IBS.
    Active infections
Prevalence of protozoal infections in industrialized countries (United States and Canada) in 21st century.  There is research to support IBS being caused by an as-yet undiscovered active infection.  Studies have shown that the nonabsorbed antibiotic Rifaximin can provide sustained relief  for some IBS patients.   While some researchers see this as evidence that IBS is related to an undiscovered agent, others believe IBS patients suffer from overgrowth of intestinal flora and the antibiotics are effective in reducing the overgrowth (known as small intestinal bacterial overgrowth).  Other researchers have focused on an unrecognized protozoal infection as a cause of IBS as certain protozoal infections  occur more frequently in IBS patients.    Two of the protozoa investigated have a high prevalence in industrialized countries and infect the bowel, but little is known about them as they are recently emerged pathogens.
Blastocystis is a single-cell organism that has been reported to produce symptoms of abdominal pain, constipation and diarrhea in patients.   Studies from research hospitals in various countries have identified high Blastocystis infection rates in IBS patients,  with thirty eight percent  being reported from London School of Hygiene & Tropical Medicine,  forty seven percent reported from the Department of Gastroenterology  at Aga Khan University in Pakistan and eighteen percent reported from the Institute of Diseases and Public Health at University of Ancona in Italy.  Reports from all three groups indicate a Blastocystis prevalence of approximately  seven percent in non-IBS patients.  Researchers have noted that clinical diagnostics fail to identify infection, and Blastocystis may not respond to treatment with common antiprotozoals.
Dientamoeba fragilis is a single-cell organism that produces abdominal pain and diarrhea.  Studies have reported a high incidence of infection in developed countries, and symptoms of patients resolve following antibiotic treatment.   One study reported on a large group of patients with IBS-like symptoms who were found to be infected with Dientamoeba fragilis, and experienced resolution of symptoms following treatment.    Researchers have noted that methods used clinically may fail to detect some Dientamoeba fragilis infections.    Also found in people without IBS.
    
Can changes in diet help IBS?
For many people, careful eating reduces IBS symptoms. Before changing the diet, keep a journal noting the foods that seem to cause distress. Then discuss these findings with the doctor. A registered dietitian can help a person make changes to the diet. For instance, if dairy products cause symptoms to flare up, try eating less of those foods. A person might be able to tolerate yogurt better than other dairy products because it contains bacteria that supply the enzyme needed to digest lactose, the sugar found in milk products. Dairy products are an important source of calcium and other nutrients. If a person needs to avoid dairy products, adequate nutrients should be added in foods or supplements should be taken.
In many cases, dietary fiber may lessen IBS symptoms, particularly constipation.  However, it may not help with lowering pain or decreasing diarrhea.  Whole grain breads and cereals, fruits, and vegetables are good sources of fiber.  High–fiber diets keep the colon mildly distended, which may help prevent spasms.  Some forms of fiber keep water in the stool, thereby preventing hard stools that are difficult to pass.  Doctors usually recommend a diet with enough fiber to produce soft, painless bowel movements.  High–fiber diets may cause gas and bloating, although some people report that these symptoms go away within a few weeks. Increasing fiber intake by two to three grams per day will help reduce the risk of increased gas and bloating.
Drinking six to eight glasses of plain water a day is important, especially if a person has diarrhea.  Drinking carbonated beverages, such as sodas, may result in gas and cause discomfort.  Chewing gum and eating too quickly can lead to swallowing air, which also leads to gas.
Large meals can cause cramping and diarrhea, so eating smaller meals more often, or eating smaller portions,  may help IBS symptoms.  Eating meals that are low in fat and high in carbohydrates such as pasta;  rice;  whole–grain breads and cereals, unless a person has celiac disease;  fruits;  and vegetables may help.
    
How does stress affect IBS?
Stress-feeling mentally or emotionally tense, troubled, angry, or overwhelmed-can stimulate colon spasms in people with IBS.  The colon has many nerves that connect it to the brain.  Like the heart and the lungs, the colon is partly controlled by the autonomic nervous system, which responds to stress.  These nerves control the normal contractions of the colon and cause abdominal discomfort at stressful times. People often experience cramps or “butterflies” when they are nervous or upset.  In people with IBS, the colon can be overly responsive to even slight conflict or stress.  Stress makes the mind more aware of the sensations that arise in the colon, making the person perceive these sensations as unpleasant.
Some evidence suggests that IBS is  affected by the immune system, which fights infection in the body.  The immune system is  affected by stress.  For all these reasons, stress management is an important part of treatment for IBS.  Stress management options include:
• stress reduction training and relaxation therapies such as meditation
• counseling and support
• regular exercise such as walking or yoga
• changes to the stressful situations in a person's life
• adequate sleep
IBS is a disorder that interferes with the normal functions of the colon.
    
What is the treatment for IBS?
    Unfortunately, many people suffer from IBS for a long time before seeking medical treatment.  Up to seventy percent of people suffering from IBS are not receiving medical care for their symptoms.  No cure has been found for IBS, but many options are available to treat the symptoms.  The doctor will prescribe the best treatments for a person's particular symptoms and encourage the person to manage stress and make dietary changes.
Medications are an important part of relieving symptoms.  The doctor may suggest fiber supplements or laxatives for constipation or medicines to decrease diarrhea, such as diphenoxylate and atropine (Lomotil) or loperamide (Imodium).  An antispasmodic is commonly prescribed, which helps control colon muscle spasms and reduce abdominal pain.  Antidepressants may relieve some symptoms.  However, both antispasmodics and antidepressants can worsen constipation, so some doctors will also prescribe medications that relax muscles in the bladder and intestines, such as belladonna alkaloid combinations and phenobarbital (Donnatal) and chlordiazepoxide and clidinium bromide (Librax).  These medications contain a mild sedative, which can be habit forming, so they need to be used under the guidance of a physician.
A medication available specifically to treat IBS is alosetron hydrochloride (Lotronex).  Lotronex has been re-approved with significant restrictions by the U.S. Food and Drug Administration (FDA) for women with severe IBS who have not responded to conventional therapy and whose primary symptom is diarrhea. However, even in these patients, Lotronex should be used with great caution because it can have serious side effects such as severe constipation or decreased blood flow to the colon.
With any medication,  even over–the–counter medications such as laxatives and fiber supplements, it is important to follow the doctor's instructions.  Some people report a worsening in abdominal bloating and gas from increased fiber intake, and laxatives can be habit forming if they are used too frequently.
Medications affect people differently, and no one medication or combination of medications will work for everyone with IBS.  Working with the doctor to find the best combination of medicine, diet, counseling, and support to control symptoms may be helpful.
    [SIZE=14pt]
Alternative medicine
Due to unsatisfactory results from medical treatments for IBS up to fifty  percent of people turn to alternative medicine.
Probiotics
Probiotics can be beneficial in the treatment of IBS, taking 10 billion to 100 billion beneficial bacteria per day is recommended for beneficial results.  However, further research is needed on individual strains of beneficial bacteria for more refined recommendations.   A number of probiotics have been found to be effective including:  Lactobacillus plantarum  and Bifidobacteria infantis;  however, one review found that only Bifidobacteria infantis showed efficacy.   Some yogurt is made using probiotics that may help ease symptoms of irritable bowel syndrome.
Herbal remedies
Peppermint oil:  Enteric coated peppermint oil capsules have been suggested for IBS symptoms in adults and children.   There is evidence of a beneficial effect of these capsules and it is recommended that peppermint be trialed in all irritable bowel syndrome patients.   Safety during pregnancy has not been established however and caution is required not to chew or break the enteric  coating  otherwise gastroesophageal reflux may occur as a result of lower esophageal sphincter relaxation. Occasionally nausea and perianal burning occur as side effects.
Iberogast:  The multi-herbal extract Iberogast was found to be significantly superior to placebo via both an abdominal pain scale and an IBS symptom score after four weeks of treatment.
– Cannabis
– Kiwifruit IBS/C
– Commiphora mukul
– Plantago ovata
There is only limited evidence for the effectiveness of other herbal remedies for irritable bowel syndrome. As with all herbs it is wise to be aware of possible drug interactions and adverse effects.
Yoga
Yoga may be effective for some with irritable bowel syndrome, especially poses which exercise the lower abdomen.
Acupuncture
Acupuncture may be worth a trial in select patients, but the evidence base for effectiveness is weak.  A meta-analysis by the Cochrane Collaboration concluded that most trials are of poor quality and that it is unknown whether acupuncture is more effective than placebo.
The goal of treatment is to relieve symptoms.
Lifestyle changes can be helpful in some cases of IBS.  For example, regular exercise and improved sleep habits may reduce anxiety and help relieve bowel symptoms.
Dietary changes can be helpful.  However, no specific diet can be recommended for IBS in general, because the condition differs from one person to another. The following changes may help:
• Avoid foods and drinks that stimulate the intestines (such as caffeine, tea, or colas)
• Avoid large meals
• Avoid wheat, rye, barley, chocolate, milk products, and alcohol
• Increase dietary fiber
Talk with your doctor before taking over-the-counter medications.
• Fiber supplements can make symptoms worse
Laxatives taken for constipation can become habit forming
No one medication will work for everyone.  Medications your doctor might prescribe:
– Anticholinergic medications (dicyclomine, propantheline, belladonna, and hyoscyamine) taken about a half-hour before eating to control colon muscle spasms
– Loperamide to treat diarrhea
– Low doses of tricyclic antidepressants to help relieve intestinal pain
– Lubiprostone for constipation symptoms
– Medications that relax muscles in the intestines[/SIZE]
     
    Counseling may help in cases of severe anxiety or depression.
Most of the time, your doctor can diagnose IBS based on your symptoms, with few or no tests.  Eating a lactose-free diet for 2 weeks may help the doctor evaluate for a possible lactase deficiency.
1. There is no test to diagnose IBS, but tests may be done to rule out other problems:
2. Blood tests to see if you have a low blood count (anemia)
3. Stool cultures to rule out an infection
    Some patients will have sigmoidoscopy or colonoscopy.  During these tests, a hollow tube is inserted through the anus.  The doctor can see through this tube.  You may need these tests if:
    •    Symptoms began later in life (over age 50)
    •     You have symptoms such as weight loss or bloody stools
    •     You have abnormal blood tests (such as a low blood count)
    •   
    Other disorders that can cause similar symptoms include:
    •    Celiac disease (chronic nutritional  disturbance)
    •    Colon cancer (although cancer rarely causes typical IBS symptoms, unless symptoms such as weight loss, blood in the stools or abnormal blood tests are present)
    •    Crohn's disease or ulcerative colitis
    •   
     
    [SIZE=22pt]Cannabinoids Treat IBS Symptoms[/SIZE]
    
Cannabinoid receptor 1 gene polymorphism and irritable bowel syndrome in the Korean population: a hypothesis-generating study.
    Abstract
OBJECTIVE:
The cannabinoids affect gastrointestinal function and are thought to be involved in the pathogenesis of irritable bowel syndrome (IBS).  We hypothesized that genetic variants of the cannabinoid receptor 1 gene (CNR1) might be associated with IBS.
    
The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome
. Abstract Irritable bowel syndrome (IBS) is a spectrum of disorders characterized by abdominal discomfort
and pain, associated with altered bowel habits.  Through gut motility, secretion and sensation may be
altered in patients with IBS, the pathophysiology of this condition remains to be fully understood.  The
endocannabinoid system is involved in the regulation of numerous gastrointestinal functions including
motility, sensation and secretion under both physiological and pathophysiological conditions.  Activation
of cannabinoid (CB)1 and CB2 receptors under various circumstances reduces motility, limits secretion and
decreases hypersensitivity in the gut.  Drugs that alter the levels of endocannabinoids in the gut also reduce
motility and attenuate in?ammation.  In this review, we discuss the role of the endocannabinoid system in
gastrointestinal physiology.  We go on to consider the involvement of the endocannabinoid system in the  context of symptoms associated with IBS and a possible role of this system in the pathophysiology and  treatment of IBS.
     
    Anecdotal evidence suggests that use of cannabis/marijuana reduces symptoms associated with Irritable Bowel Syndrome (IBS).
    Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common disorder that affects the large intestine (colon).  Irritable bowel â€¨syndrome commonly causes cramping, abdominal pain, bloating gas, diarrhea and constipation.  Unlike intestinal diseases such as celiac disease, ulcerative colitis and Crohn's disease, irritable bowel syndrome does not cause inflammation or changes in bowel tissue or increase the risk of colorectal cancer.
Marijuana can be used to treat many of the symptoms of irritable bowel syndrome that are qualifying medical conditions under state medical marijuana laws.  Marijuana “cools the gut.” It slows down the muscle contractions that move food through the stomach and intestines and reduces the secretion of liquid into the intestines associated with diarrhea .  Marijuana also controls the muscle spasms associated with diarrhea.
     
      Mayo Clinic, Irritable Bowel Syndrome
Constituents in marijuana called cannabinoids interact with receptors (called CB1 receptors) in the enteric nervous system (the part of the nervous system that directly controls the gastrointestinal system) and with CB1 receptors in the brain.  The cannabinoids in marijuana that contribute to its ability to treat the symptoms of irritable bowel syndrome include tetrahydrocannabinol (THC) and, possibly, cannabidiol (CBD).  People with irritable bowel syndrome should use marijuana strains that contain a relatively high concentration of THC.  THC binds to CB1 receptors on cells in the gut and brain and acts as an agonist to inhibit emptying of the stomach and transit of food through the intestines .  CBD appears to have little effect on intestinal motility on its own, but it synergizes the effect of THC .  Cannabinoids that activate CB2 receptors (agonists) like CBD may alter intestinal mobility under pathophysiological conditions .
.
I
"Indica strains of the plant are most beneficial  for Treating symptoms of IBS due to their muscle relaxing properties
     
     
     
    Medical Marijuana relieves IBS symptoms
    Many IBS patients have found that the cramping, abdominal pain, and irregularity of bowel movements are relieved with marijuana.  Marijuana has been shown to decrease intestinal muscle spasms, decrease nausea, and increase appetite.  There are also reports that marijuana works well as an anti-inflammatory, helping to alleviate inflammation in the bowel.  Marijuana is well known to help relieve anxiety and induce a relaxed state for most people;  this relief of anxiety has been reported by some patients to help calm the symptoms of IBS triggered by stress.  Many patients use a combined natural approach of dietary changes, stress-reducing activities like yoga or meditation, and marijuana with good improvement in most if not all their symptoms.
     
    
Cannabinoids and the gastrointestinal tract -Department of Physiological Chemistry, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.ʉ۬In the past centuries, different preparations of marijuana have been used for the treatment of gastrointestinal (GI) disorders, such as GI pain, gastroenteritis and diarrhea. Delta9-tetrahydrocannabinol (THC; the active component of marijuana), as well as endogenous and synthetic cannabinoids, exert their biological functions on the gastrointestinal tract by activating two types of cannabinoid receptors, cannabinoid type 1 receptor (CB1 receptor) and cannabinoid type 2 receptor (CB2 receptor). While CB1 receptors are located in the enteric nervous system and in sensory terminals of vagal and spinal neurons and regulate neurotransmitter release, CB2 receptors are mostly distributed in the immune system, with a role presently still difficult to establish. Under pathophysiological conditions, the endocannabinoid system conveys protection to the GI tract, eg from inflammation and abnormally high gastric and enteric secretion. For such protective activities, the endocannabinoid system may represent a new promising therapeutic target against different GI disorders, including frankly inflammatory bowel diseases (eg, Crohn's disease), functional bowel diseases (eg, irritable bowel syndrome), and secretion- and motility-related disorders.
     
    Medical Marijuana and IBS (Irritable Bowel Syndrome)
Irritable Bowel Syndrome (IBS) is a common syndrome that affects the large intestine.  The most common symptoms are cramping, abdominal pain, bloating gas, constipation and diarrhea.  Although the symptoms can be severe, there appears to be no long term permanent damage to the bowel.  Many patients with IBS find that emotional stress worsens their symptoms.  IBS is usually a chronic condition where symptoms can come and go, depending on diet and stress factors.
IBS is different from Inflammatory Bowel Disease (IBD) which includes Crohn's Disease and Ulcerative Colitis.  These diseases cause permanent changes in the bowel that can be severe and can even increase the risk of colorectal cancer. This is why it is very important to get the correct diagnosis from your doctor before you make any decisions on how to proceed with treatment.
Conventional treatment for IBS includes dietary changes, stool softeners, anti-spasmotic medications, laxatives, and anti-depressants.  Many patients find that these treatments don't work or have unwanted side effects.  Many patients have opted to try a more natural approach to their treatment and have found herbal medication (including marijuana) to be helpful.
Many IBS patients have found that the cramping, abdominal pain, and irregularity of bowel movements are relieved with marijuana. Marijuana has been shown to decrease intestinal muscle spasms, decrease nausea, and increase appetite.  There are also reports that marijuana works well as an anti-inflammatory, helping to alleviate inflammation in the bowel.  Marijuana is well known to help relieve anxiety and induce a relaxed state for most people; this relief of anxiety has been reported by some patients to help calm the symptoms of IBS triggered by stress.  Many patients use a combined natural approach of  dietary changes, stress-reducing activities like yoga or meditation, and marijuana with good improvement in quality of life.
     
    Marijuana and IBS
    Find relief from the pain associated with IBS - Irritable Bowel Syndrome with medical marijuana.
    IBS is an enigmatic problem with no known cause and no effective cure or remedy. IBS is sometimes referred to as spastic colon. IBS symptoms include stomach pain, constipation, diarrhea, bloody stools, nausea, nervousness and loss of appetite. The pain and nausea from having IBS are daily. Prescription drug therapy is often not very useful; the drugs most commonly used are Bentyl and Imodium and have even caused intolerable side effects.
Those who have IBS claim using marijuana reduces the pain, is effective in curbing abdominal cramps and eliminates nausea. Marijuana also improves their appetite, and reduces emotional stress, itself being a strong suspect in the cause of IBS. Marijuana has been described as being the best of all treatments in relieving the symptoms of IBS.
     
     
    IBS relief using CBD rich Sour Tsunami strain
“I am a IBD & IBS patient that has been doing the high CBD sour tsunami hemp oil treatment now since march 4th along with my other diet and supplement regiment.  Within a few days great relief to spasms, pain, bleeding and bowel incontinence had been seen.  Now up to full dosage and a few weeks into treatment I have much greater relief.  Down to one bowl movement a day (from 10-20), and stools are now formed and solid.  I have fully adjusted to meds.  and now have energy during day, more stamina, and sleep unbelievably well at night.  Some nights I can get eight to ten hours straight of real REM sleep which has helped healing tremendously.  The other effects worth noting are the emotional effects. â€¨The oil also keeps any stress and anxiety so common with IBD and IBS under control better than any other meds.  out there and totally safe.  The high CBD medicine makes it possible to have great relief, healing and still function during the day with no restrictive effects.  I can now leave my bathroom and house and get things done and feel human again!   So far,   I cannot  say enough about the effectiveness of this treatment.   I still have a few weeks to go.
    - H.J, Northern California
     
    Diarrhea
     
    The condition of having three or more loose or liquid bowel movements per day.
It is a common cause of death in developing countries and the second most common cause of infant deaths worldwide.  The loss of fluids through diarrhea can cause dehydration and electrolyte imbalances.  In 2009 diarrhea was estimated to have caused  1.1 million deaths in people aged five and over and 1.5 million deaths in children under the age of five.   Oral rehydration salts and zinc tablets are the treatment of choice and have been estimated to have saved  fifty  million children in the past twenty five years.
Osmotic:
Osmotic diarrhea occurs when too much water is drawn into the bowels.  This can be the result of maldigestion (e.g., pancreatic disease or celiac disease),  in which the nutrients are left in the lumen to pull in water.  Osmotic diarrhea can also be caused by osmotic laxatives (which work to alleviate constipation by drawing water into the bowels).  In healthy individuals, too much magnesium or vitamin C or undigested lactose can produce osmotic diarrhea and distention of the bowel.  A person who has lactose intolerance can have difficulty absorbing lactose after an extraordinarily high intake of dairy products.  In persons who have fructose malabsorption,  excess fructose intake can also cause diarrhea.  High-fructose foods that also have a high glucose content are more absorbable and less likely to cause diarrhea.  Sugar alcohols such as sorbitol (often found in sugar-free foods) are difficult for the body to absorb and, in large amounts,  may lead to osmotic diarrhea.   Osmotic diarrhea stops when offending agent (e.g. milk, sorbitol) is removed.
Exudative:
Exudative diarrhea  occurs with the presence of blood and pus in the stool.  This occurs with inflammatory bowel diseases, such as Crohn's disease or ulcerative colitis, and other severe infections such as E. coli or other forms of food poisoning.
Motility-related:
Motility-related diarrhea is caused by the rapid movement of food through the intestines (hypermotility).  If the food moves too quickly through the gastrointestinal tract, there is not enough time for sufficient nutrients and water to be absorbed.  This can be due to a vagotomy or diabetic neuropathy, or a complication of menstruation.  Hyperthyroidism can produce hypermotility and lead to pseudodiarrhea and occasionally real diarrhea.  Diarrhea can be treated with antimotility agents (such as loperamide).  Hypermotility can be observed in people who have had portions of their bowel removed, allowing less total time for absorption of nutrients.
    [SIZE=18pt]Inflammatory:[/SIZE]
    Inflammatory diarrhea occurs when there is damage to the mucosal lining or brush border, which leads to a passive loss of protein-rich fluids, and a decreased ability to absorb these lost fluids.  Features of all three of the other types of diarrhea can be found in this type of diarrhea.  It can be caused by bacterial infections, viral infections, parasitic infections, or autoimmune problems such as inflammatory bowel diseases.  It can also be caused by tuberculosis, colon cancer, and enteritis
    Dysentery:
Generally, if there is blood visible in the stools, it is not diarrhea, but dysentery.  The blood is trace of an invasion of bowel tissue.  Dysentery is a symptom of, among others, Shigella, Entamoeba histolytica, and Salmonella.
     
    Diagram of the human gastrointestinal tract.
    
Diarrhea is most commonly due to viral gastroenteritis with rotavirus, which accounts for forty percent of cases in children under five.   In travelers however,  bacterial infections predominate.   Various toxins such as mushroom poisoning and drugs can also cause acute diarrhea.
Chronic diarrhea can be the part of the presentations of a number of chronic medical conditions affecting the intestine.  Common causes include ulcerative colitis, Crohn's disease, microscopic colitis, celiac disease, irritable bowel syndrome and bile acid malabsorption.
    [SIZE=18pt]Infections:[/SIZE]
    Infectious diarrhea:
There are many causes of infectious diarrhea, which include viruses, bacteria and parasites.   Norovirus is the most common cause of viral diarrhea in adults,  but rotavirus is the most common cause in children under five years old.   Adenovirus types 40 and 41,  and astroviruses cause a significant number of infections.
The bacterium Campylobacter is a common cause of bacterial diarrhea, but infections by Salmonellae, Shigellae and some strains of Escherichia coli (E.coli) are frequent.
In the elderly, particularly those who have been treated with antibiotics for unrelated infections, a toxin produced by Clostridium difficile often causes severe diarrhea.
Parasites do not often cause diarrhea except for the protozoan Giardia, which can cause chronic infections and severe diarrhea. â€¨Other infectious agents such as parasites and bacterial toxins also occur.   In sanitary living conditions where there is ample food and a supply of clean water, an otherwise healthy person usually recovers from viral infections in a few days.  However, for ill or malnourished individuals, diarrhea can lead to severe dehydration and can become life-threatening.
Malabsorption:
Malabsorption is the inability to absorb food fully, mostly from disorders in the small bowel, but also due to maldigestion from diseases of the pancreas.
    [SIZE=18pt]Causes include:[/SIZE]
    • Enzyme deficiencies or mucosal abnormality, as in food allergy and food intolerance, (e.g. celiac disease (gluten intolerance), lactose intolerance (intolerance to milk sugar, common in non-Europeans) and  fructose malabsorption.
• Pernicious anemia (impaired bowel function due to the inability to absorb vitamin B12),
• Loss of pancreatic secretions (may be due to cystic fibrosis or pancreatitis),
• Structural defects, like short bowel syndrome (surgically removed bowel) and radiation fibrosis (usually following cancer treatment and other drugs, including agents used in chemotherapy),
• Certain drugs (like orlistat, which inhibits the absorption of fat).
    [SIZE=15pt]Inflammatory bowel disease:[/SIZE]
    The two overlapping types here are of unknown origin:
• Ulcerative colitis is marked by chronic bloody diarrhea and inflammation mostly affects the distal colon near the rectum.
• Crohn's disease typically affects fairly well demarcated segments of bowel in the colon and often affects the end of the small bowel.
Irritable bowel syndrome:
Another possible cause of diarrhea is irritable bowel syndrome (IBS) which usually presents with abdominal discomfort relieved by defecation and unusual stool (diarrhea or constipation) for at least 3 days a week over the previous  three months.   Symptoms of diarrhea-predominant IBS can be managed through a combination of dietary changes, soluble fiber supplements, and/or medications such as loperamide or codeine.  About thirty percent  of patients with diarrhea-predominant IBS have bile acid malabsorption diagnosed with an abnormal SeHCAT test. 
    Other causes:
     
    • Diarrhea can be caused by chronic ethanol ingestion.
• Ischemic bowel disease.  This usually affects older people and can be due to blocked arteries.
• Microscopic colitis, a type of inflammatory bowel disease where changes are only seen on histological examination of colonic biopsies.
• Bile salt malabsorption (primary bile acid diarrhea) where excessive bile acids in the colon produce a secretory diarrhea.
• Hormone-secreting tumors: some hormones (e.g., serotonin) can cause diarrhea if excreted in excess (usually from a tumor).
• Chronic mild diarrhea in infants and toddlers may occur with no obvious cause and with no other ill effects; this condition is called toddler's diarrhea.
    [SIZE=18pt]Management:[/SIZE]
    In many cases of diarrhea, replacing lost fluid and salts is the only treatment needed. This is usually by mouth – oral rehydration therapy – or, in severe cases, intravenously.[1] Diet restrictions such as the BRAT diet are no longer recommended.  Research does not support the limiting of milk to children as doing so has no effect on duration of diarrhea.
Medications such as loperamide (Imodium), bismuth subsalicylate may be beneficial, however they may be contraindicated in certain situations
    [SIZE=18pt]Cannabinoids stop diarrhea, little or no side effects:[/SIZE]
    The overall opinion of enlightened people in the medical community is that medical cannabis can interact with the endogenous cannabinoid system to reduce problems associated with nausea, vomiting, gastric ulcers, irritable bowel syndrome, Crohn's disease, secretory diarrhea, paralytic ileus and gastroesophageal reflux disease.
Cannabinoid receptor agonists delay gastric emptying in humans as well as in rodents, and they may also inhibit human gastric acid secretion.
    It is also worth noting that there have been a number of anecdotal accounts of the effective use of cannabis in the past against dysentery and cholera.   The major active constitutent of the plant Cannabis sativa (marijuana), THC, and a variety of natural and synthetic cannabinoids have been shown to possess... anti-inflammatory activities...
    Results indicate that the endogenous cannabinoid system represents a promising therapeutic target for the treatment of intestinal disease conditions characterized by excessive inflammatory responses.   Cannabis is an adaptogenic immune system modulator that can increase or decrease immune systems function in ways that almost always contribute to healthier outcomes.
    The use of medical marijuana to treat digestive system problems is time-tested, and is usually a safer intervention than the use of pharmaceutical drugs or surgery.
Cannabis helps combat cramping that accompanies many GI disorders because cannabinoids relax contractions of the smooth muscle of the intestines.  Research shows that the body's own cannabinoids, known as anandamides, affect neurological systems that control the gastrointestinal system.  External and internal cannabinoids strongly control gastrointestinal motility and inflammation.  They also have the ability to decrease gastrointestinal fluid secretion and inflammation.  This means that cannabis can be useful to stop ulcers and other syndromes.
The plant can be used to treat a variety of diseases and symptoms related to the gastrointestinal system.
Cannabis has been used for centuries in the medicinal treatment of gastrointestinal disorders.   Dr. Anita Holdcroft of Hammersmith Hospital...has reported the results of a placebo-controlled trial of cannabis in a patient with severe chronic pain of gastrointestinal origin...
    The patient's demand for morphine was substantially lower during treatment with cannabis than during a period of placebo treatment.
Studies indicate that cannabinoids in marijuana bind with cannabinoid receptors in the digestive tract, especially the small and large intestine, causing muscle relaxation, reduction of inflammation, analgesia, increased nerve-muscle coordination, anti-emesis, and relief of spasms such as those that cause diarrhea.
    Control of secretory diarrhea  and colorectal cancer growth by cannabinoids in the gut.
These findings show that Cannabinoids  inhibit neurally mediated secretion via Cannabinoid CB1-receptors and may be useful in some forms of diarrhea.
     
     Inflammatory Bowel
     
    Two forms of IBD are Crone's disease and ulcerative colitis.
    
The main difference between Crohn's disease and UC is the location and nature of the inflammatory changes.  Crohn's can affect any part of the gastrointestinal tract, from mouth to anus (skip lesions), although a majority of the cases start in the terminal ileum.  Ulcerative colitis, in contrast, is restricted to the colon and the rectum.
Microscopically, ulcerative colitis is restricted to the mucosa (epithelial lining of the gut), while Crohn's disease affects the whole bowel wall.
     
     
     
    Crohn's disease remains a disease of unknown etiology.  It occurs in about seven out of 100,000 population, typically in people of European decent.  What can be said about it is that the immune system in the GI tract is over reactive, misguided and destructive to the intestine.  â€¨Both of these diseases  are thought to be caused by a mix of environmental and genetic factors – so if you have the genetic susceptibility to the disease and are then subjected to environmental triggers, such as diet, stress, or bacterial imbalance,  the chances are you will develop the defective immune response that leads to the unpleasant symptoms.Finally, Crohn's disease and ulcerative colitis present with extra-intestinal manifestations (such as liver problems, arthritis, skin manifestations and eye problems) in different proportions.
Rarely, a definitive diagnosis of neither Crohn's disease nor ulcerative colitis can be made because of idiosyncrasies in the presentation.  In this case, a diagnosis of indeterminate colitis may be made.
    
In 2005,  New Scientist published a joint study by Bristol University and the University of Bath on the apparent healing power of cannabis on IBD.  Reports that cannabis eased IBD symptoms indicated the possible existence of cannabinoid receptors in the intestinal lining, which respond to molecules in the plant-derived chemicals.  CB1 cannabinoid receptors – which are known to be present in the brain – exist in the endothelial cells, which line the gut.  It is thought that they are involved in repairing the lining of the gut when damaged.  The team deliberately damaged the cells to cause inflammation of the gut lining and then added synthetically produced cannabinoids;  the result was that the gut started to heal:   the broken cells were repaired and brought back closer together to mend the tears.  It is believed that in a healthy gut, natural endogenous cannabinoids are released from endothelial cells when they are injured, which then bind to the CB1 receptors.  The process appears to set off a wound-healing reaction, and when people use cannabis, the cannabinoids bind to these receptors in the same way.  Previous studies have shown that CB1 receptors located on the nerve cells in the gut respond to cannabinoids by slowing gut motility, therefore reducing the painful muscle contractions associated with diarrhea.  The team also discovered another cannabinoid receptor, CB2, in the guts of IBD sufferers, which was not present in healthy guts.  These receptors, which also respond to chemicals in cannabis, appear to be associated with apoptosis – programmed cell death – and may have a role in suppressing the overactive immune system and reducing inflammation by mopping up excess cells.
    
Researchers in the United Kingdom have shown that two compounds found within the cannabis plant – THC and CBD (Cannabidiol) – do interact with gut function.  This proves,  as many sufferers have testified,  that medical marijuana does provide an effective treatment for inflammatory bowel diseases such as Crohn's and Ulcerative Colitis.
    

    
While it has been known for a long time that cannabis is a powerful anti-inflammatory, the discovery that it actually reintegrates the intestinal lining is a new one.
    
Researchers found that plant-derived cannabinoids--  encouraged tighter bonds between the cells that form that gut barrier, therefore making it less leaky.
    
In very basic terms, people with Crohn's disease have a defective barrier to their gut, which allows bacteria to leak into the intestinal tissue and set up an inflammatory response.  It seems then that the answer to the problems posed by this illness is to restore integrity to the gut barrier.
    
Physicians in the Society of Cannabis Clinicians conducted a pilot study of the effect of cannabis on Crohn's disease in California.  For all signs and symptoms evaluated in the study,  the patients described marked improvements with the use of cannabis.  Beneficial effects were reported for appetite, pain, nausea, vomiting, fatigue, activity, and depression.  Patients also reported that cannabis use resulted in weight gain, fewer stools per day and fewer flare-ups.  Cannabis-using Crohn's patients not only report significant relief of their symptoms, they are also able to reduce the amount of immunosuppressive medications that have been a mainstay of conventional treatment.  Imuran, methotrexate, 6 MP, and Remicade (an anti-TNF drug) are greatly reduced.  Asacol and Pentasa brands of Mesalamine, an anti-inflammatory medication with immuno-modulating properties is also reduced in many cases.  Steroids are noted to be reduced and often eliminated.
    
The immunosuppressives cause the same side effects that the disease causes:  nausea, vomiting, abdominal pain, and diarrhea.  Mesalamine frequently was reported to cause rash, itching, and photosensitivity.  Steroids have a host of common side effects including anxiety, depression, irritability, nausea, vomiting, abdominal pain;  and, with chronic use, bone thinning, glucose intolerance, peptic ulcers, and the Cushingoid state.
     
     
     

     
  2. If you need it it's better then pills if you're 18 it doesn't matter what your parents think your an adult. Explain your situation to them if they care about you they will understand no one wants a loved one to live in pain.
     
  3. Offer your parents a couple tokes each, they'll understand a lot more when they read that!

    To the parents, what do ya reckon?


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