oral cannabis bioavailability-questions for data

That's what they said right before the cuffs went on....

 

@clayi21
I'm Clay and I've been a daily consumer of cannabis for the past 12 years. I prefer edibles and tinctures and have been researching the low bioavailability of orally consumed cannabis. I'm currently in Business School at the University of Georgia and have a project regarding a theoretical business involving cannabis infusions and their absorption issues. I need to conduct a minimum of 10 interviews per week for a total of 8 weeks to collect data about the target consumers. My ideal consumer is someone consumes cannabis orally on a regular basis and who makes their own cannabis infusions at home (oils, tinctures, glycerin etc...). If that sounds familiar and you feel like helping me out here are the questions I'm asking. Please feel free to post answers here on the thread or message me privately. I won't use anyones names/profile in my report, its strictly to gather consumer data and habits. Many thanks to those who have already helped me out and I really appreciate any help from the edibles community, thanks!


Please state your Age, Male or Female, State of Residence
Over 60, Male, California

1. How long have you been consuming cannabis and how often do you consume it?
44 years. Daily.
2. How often is it orally consumed cannabis (edibles, tinctures etc)?
Daily since 2013
3. Do you use cannabis for medical or recreational purposes?
Medical now, Recreational for most of 40 years
4. How much money do you spend on cannabis per month?
Since I grow I spend very little
5. Do you make your own cannabis infusions? If so, what types?
Yes, Kief-Hash, Coconut oil, Lecithin Capsules
6. Are you aware of your total dose amount (active ingredients) every time you consume cannabis?
150 milligrams per day (estimated)
7. Do you feel consistent effects from orally consumed cannabis?
Yes.
8. Do you believe orally consumed cannabis has high or low rates of absorption into the human circulatory system?
High.
9. Do you use any specific methods or ingredients to try to improve the solubility of your infusions? If so what?[/QUOTE]
Lecithin
=====================================
I've answered privately but since everything Cannabis related I do is an open book here I'll post again to help encourage any others to assist publicly or privately as they see fit. Everything I've answered can be found in my public threads anyway.

BNW

 

And I'm actually responsible for the first question in the survey. My thoughts on the subject are an open book as well and are spread out over 1000 pages in this very forum. There's no way I could say no to clayi21's request.

This was my private response.

You should probably add another question to your study and it should be at the head of the list. It's a very important factor in how folks view cannabis and colors the answers we provide. For example, users like myself who grew up in a different culture are going to lend a more visceral tone to their responses than someone who's experiencing the modern marketplace. That question is "How long have you been consuming cannabis?".

I'll answer that question. It's been fifty years of heavy usage.
I'm male
I live in AZ
I consume cannabis as often as possible. Not as much lately due to fixed income but I still use it daily.
If I had the money to spend it would be hundreds but that's not a good question now due to income. I may not spend a dime and still use cannabis daily thanks to friends who gift me enough to get by. When I was doing those tests you were inquiring about I spent several thousand dollars at once buying a few pounds to experiment with and I have good friends. I may not always have something to smoke but I do have other things.
I prefer to smoke
I consume for both medicinal and recreational purposes.
I ingest edibles in some form about 5 of 7 days per week.
I make my own.
I am aware of my dosages
They are consistent. I know what I'm doing.

I hope this helps.

One question I left out: In my late 60's.

 

Why do you say "low bioavailability of orally consumed cannabis"? Are you saying it takes more to get medicated when eaten? Or that cannabinoids in general have a lesser effect when eaten? Just looking for a little clarification dude.

 

Soluble with what? They are FAT soluble. Bioavailability depends on a fat carrier in the DT. That's literally all there is to it. I've learned that what I eat with the weed and when determines the level of effect. The best method I've come up with so far is to use de-carbed, powdered weed like a salad topping with any sort of meal containing a decent amount of fat. I had it on a bowl of beef chili and cheese yesterday and got pretty hammered.

 

Tinctures - made with an oil carrier and directly absorbed under-the-tongue. Direct absorption, no digestion involved. I've made a couple in the past year, with good results, but it's a more fussy, much more time-consuming prep method, so done with that.

 

Inconsistencies in the decarb lead to crappy edibles with weak results. The pass made through the liver via digestion is exactly why edibles work so well.

As far as low bioavailability goes, we use fat as a carrier. That way when you eat you take advantage of you digesting fats first. Cannabinoids are fat soluble so digestion the fat in the oil is digesting the cannabinoids.

Out of everything I have tried, oven activation at 240*F for 40 minutes is the sweet spot. A little lecithin, a fatty oil like coconut and its all you need. Add a freezing cycle, then a 220*F for 20 mins, then another freeze, then 220*F for 20 mins and its ready to go. Add to anything or eat it straight from the jar.

Dosage is about 1/4 of a gram per dose for most average users. 1/2 of a gram is about right for me. Also, you dont green out on edibles, if you eat to much youll get higher and higher till youre horribly ill. Like for days ill.

The hardest part of it all? Getting through the bullshit and find real info on making potent, consisten edibles. It comes down to the oven decarb. Get that down and youll be set. Everything falls into place.

 

Exactly. That is why I have promoted the Ardent Lyft every time I get on this topic. It takes all the guess work and actually all the work period, out of decarb.