CBD Nice Study - CBD vs Cancer

This is a nice review (where they look at a lot of studies and put all the ideas together in a much more readable overview ). CBD can have quite an effect on many types of cancer, plus it can help relieve several chemo side effects (anxiety, nausea, neuropathic pain, etc.). Besides talking about CBD vs cancer, this review will give you an education on how your endocannabinoid system works (your endocannabinoids fight cancer, too) . The link leads to the full study.

Cannabidiol (CBD) in Cancer Management. (Australia) (full – 2022 Cannabidiol (CBD) in Cancer Management

Simple Summary
Cannabidiol (CBD) is one of the main constituents of the plant Cannabis sativa. Surveys suggest that medicinal cannabis is popular amongst people diagnosed with cancer. CBD is one of the key constituents of cannabis, and does not have the potentially intoxicating effects that tetrahydrocannabinol (THC), the other key phytocannabinoid has. Research indicates the CBD may have potential for the treatment of cancer, including the symptoms and signs associated with cancer and its treatment. Preclinical research suggests CBD may address many of the pathways involved in the pathogenesis of cancers. Preclinical and clinical research also suggests some evidence of efficacy, alone or in some cases in conjunction with tetrahydrocannabinol (THC, the other key phytocannabinoid in cannabis), in treating cancer-associated pain, anxiety and depression, sleep problems, nausea and vomiting, and oral mucositis that are associated with cancer and/or its treatment. Studies also suggest that CBD may enhance orthodox treatments with chemotherapeutic agents and radiation therapy and protect against neural and organ damage. CBD shows promise as part of an integrative approach to the management of cancer.

Abstract
The plant Cannabis sativa has been in use medicinally for several thousand years. It has over 540 metabolites thought to be responsible for its therapeutic effects. Two of the key phytocannabinoids are cannabidiol (CBD) and tetrahydrocannabinol (THC). Unlike THC, CBD does not have potentially intoxicating effects. Preclinical and clinical research indicates that CBD has a wide range of therapeutic effects, and many of them are relevant to the management of cancer. In this article, we explore some of the potential mechanisms of action of CBD in cancer, and evidence of its efficacy in the integrative management of cancer including the side effects associated with its treatment, demonstrating its potential for integration with orthodox cancer care.

Keywords: cannabidiol, cannabis, endocannabinoid system, cancer, tumours



Granny

 

If folks had read the studies that I have, we would either have fully legal cannabis by the 4th of July...... or a revolution! Here's a few examples of WHY cannabis NEEDS to be fully legal. @JMcGD You might want to point out these facts at the next meeting!

Alzheimer's- In “Efficacy of Cannabinoids in a Pre-Clinical Drug-Screening Platform for Alzheimer’s Disease “ (2019) they found “Nine of the 11 cannabinoids have the ability to protect cells in four distinct phenotypic neurodegeneration screening assays, including those using neurons that lack CB1 and CB2 receptors. They are able to remove intraneuronal Aβ, reduce oxidative damage, and protect from the loss of energy or trophic support.” ( FYI- Aβ = amyloid plaque. The effective cannabinoids were CBC, CBD, CBDA, CBDV, CBG, CBGA, CBN, THC, and THCA.)

Brain trauma - In “Effect of Marijuana Use on Outcomes in Traumatic Brain Injury” (2014) they found that “Overall mortality was 9.9 per cent, however, mortality in the THC(+) group (2.4%) was significantly decreased compared with the THC(-) group (11.5%)” Effect of marijuana use on outcomes in traumatic brain injury - PubMed

Crime- “In a retrospective analysis comparing crime data in neighbouring American states, Washington and Oregon, revealed that reported rape, property crimes, and thefts all decreased by 15–30%, 10–20%, and 13–22% respectively after legalization in Washington. Moreover, the prevalence of these crimes occurring across the border where recreational cannabis use is illegal, in Oregon, remained the same.” “International Perspectives on the Implications of Cannabis Legalization: A Systematic Review & Thematic Analysis” (MDPI - 2019) International Perspectives on the Implications of Cannabis Legalization: A Systematic Review & Thematic Analysis

Covid -"Like Δ9-tetrahydrocannabinol (Δ9-THC), the most well-studied cannabinoid, CBD decreased lung inflammation in a murine model of acute lung injury potentially through the inhibition of proinflammatory cytokine production by immune cells and suppressing exuberant immune responses. CBD can inhibit the production of proinflammatory cytokines like interleukin (IL)-2, IL-6, IL-1α and β, interferon gamma, inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and tumor necrosis factor-α that have been associated with SARS-CoV2 induced multi-organ pathology and mortality." From "SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation?”
SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation? - ScienceDirect

Diabetes -“Marijuana Compound May Help Stop Diabetic Retinopathy Marijuana Compound May Help Stop Diabetic Retinopathy “Lab Notes: Pot Has Benefits for Diabetic Hearts” http://www.medpagetoday.com/LabNotes/LabNotes/23853 and “Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress”( Beneficial effects of a Cannabis sativa extract treatment on diabetes-induced neuropathy and oxidative stress - PubMed).

Epilepsy - "Chronic administration of cannabidiol to healthy volunteers and epileptic patients" (PubMed - 1980) where "4 of the 8 CBD subjects remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition." And even earlier, “Anticonvulsant nature of marihuana smoking” (PubMed/JAMA – 1975).

Heart Attacks - “We report several new observations regarding the effect of marijuana use on outcomes following AMI (Acute Myocardial Infarction = a heart attack). Most surprisingly, it appears that marijuana use is associated with decreased mortality post AMI.” From “MARIJUANA USE AND SHORT-TERM OUTCOMES IN PATIENTS HOSPITALIZED FOR ACUTE MYOCARDIAL INFARCTION” http://content.onlinejacc.org/article.aspx?articleid=2508971&_ga=1.2577849.863088085.1460727742

IQ- Prohibitionists like to bring up the Dunedin study that supposedly showed a 8 point drop in IQ. However, the study was critiqued like this- “Although it would be too strong to say that the results have been discredited, the methodology is flawed and the causal inference drawn from the results premature.” From Correlations between cannabis use and IQ change in the Dunedin cohort are consistent with confounding from socioeconomic status. (PubMed) Correlations between cannabis use and IQ change in the Dunedin cohort are consistent with confounding from socioeconomic status
Lung Cancer - “Cannabis smoking and lung cancer risk: pooled analysis in the International Lung Cancer Consortium” Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium - PubMed “Our pooled results showed no significant association between the intensity, duration, or cumulative consumption of cannabis smoke and the risk of lung cancer”.

Marriage- Couples' Marijuana Use Is Inversely Related to Their Intimate Partner Violence Over the First 9 Years of Marriage. (USA) (full – 2014) Couples’ marijuana use is inversely related to their intimate partner violence over the first nine years of marriage The title says it- More cannabis = less violence! Also....Marijuana Smokers Are Moral And Selfless In Romantic Relationships, Survey Suggests (news – 2014) Marijuana Smokers Are Moral And Selfless In Romantic Relationships, Survey Suggests and “Regular marijuana users have more sex, study says” (news – 2017) Regular marijuana users have more sex, study says | CNN

Migraines- In "Effects of MEDlCAL MARlJUANA on Migraine Headache Frequency in an Adult Population" https://accpjournals.onlinelibrary.wiley.com/doi/10.1002/phar.1673 they came to the "Conclusion - The frequency of migraine headache was decreased with MEDlCAL MARlJUANA use."

Obesity- "Are cannabis users less likely to gain weight? Results from a national 3-year prospective study" (2019) where "Cross-sectional epidemiological studies in humans indicate lower prevalence of obesity in cannabis users." and "Evidence shows attenuated body mass index gain for cannabis-use subgroups when compared with never-users." Are cannabis users less likely to gain weight? Results from a national 3-year prospective study And “Marijuana use, diet, body mass index, and cardiovascular risk factors (from the CARDIA study)” found that “users who had consumed Cannabis for more than 1800 days over 15 years consumed on average 619 more calories/day than nonusers, yet showed no difference in BMI.” Marijuana use, diet, body mass index, and cardiovascular risk factors (from the CARDIA study) - PubMed

PTSD- “Greater than 75% reduction in CAPS symptom scores were reported when patients were using cannabis compared to when they were not.” From “PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program” http://www.tandfonline.com/doi/full/10.1080/02791072.2013.873843#tabModule (tandfonline - 2014).

Safety -“Marijuana: Medical Applications, Recreational Use and Substance Abuse Disorders” which is in the Encyclopedia of Mental Health (2nd edition- 2016) “In recent years it has been used by millions as a recreational drug. Extensive research has found few serious consequences from its use. It causes no deaths and is less addictive than most other intoxicating substances.” (FYI Common aspirin can kill by overdose and kills several people every year. Yet even the DEA admits - “No death from overdose of marijuana has been reported.” https://www.dea.gov/sites/default/files/2020-06/Marijuana-Cannabis-2020_0.pdf)


Strokes - “Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage” (PubMed – 2016) where “CB+ patients had milder ICH (IntraCerebral Hemorrhage) presentation and less disability at discharge.”

As for the origin of cannabis prohibition, we need look no further than the late Harry Anslinger's quotes!


“...the primary reason to outlaw marijuana is its effect on the degenerate races.”

“There are 100,000 total marijuana smokers in the US, and most are Negroes, Hispanics, Filipinos and entertainers. Their Satanic music, jazz and swing, result from marijuana usage. This marijuana causes white women to seek sexual relations with Negroes, entertainers and any others.”

“Reefer makes darkies think they're as good as white men.”

Or consider this quote from John Ehrlichman, White House counsel to President Nixon on the rationale of the War on Drugs.

"Look, we understood we couldn't make it illegal to be young or poor or black in the United States, but we could criminalize their common pleasure. We understood that drugs were not the health problem we were making them out to be, but it was such a perfect issue...that we couldn't resist it."

If You're Black and You Like Marijuana, You're 3.67 Times More Likely to Be Arrested http://www.takepart.com/article/201...-project-reveals-intersection-of-race-and-pot

“REPORT: More than 90% of marijuana arrests in NYC are people of color” https://www.businessinsider.in/REPO...-are-people-of-color/articleshow/52542267.cms

And that's all I'm going to say since this is raising my blood pressure!

Granny