CBD New Study - Synthetic CBD for Breast and brain cancer

October is National Breast Cancer Awareness Month. Breast cancer is still the second leading cause of cancer death in women.The chance that a woman will die from breast cancer is about 1 in 37. (October is Breast Cancer Awareness Month: What You Need to Know and How You Can Help)

Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol
Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol

Background/Aim: Cannabinoids are widely used in the management of pain, nausea and cachexia in cancer patients. However, there has been no objective clinical evidence of any anticancer activity yet. The aim of this study was to assess the effects of pharmaceutical-grade synthetic cannabidiol on a range of cancer patients. Patients and Methods: We analysed the data routinely collected, as part of our treatment program, in 119 cancer patients over a four-year period. Results: Clinical responses were seen in 92% of the 119 cases with solid tumours including a reduction in circulating tumour cells in many cases and in other cases, a reduction in tumour size, as shown by repeat scans. No side-effects of any kind were observed when using pharmaceutical grade synthetic cannabidiol. Conclusion: Pharmaceutical-grade synthetic cannabidiol is a candidate for treating breast cancer and glioma patients.

The link is to the full study. And if the synthetic works, so should natural CBD. But this isn't the first study to look at this anti-cancer effect from CBD!

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. (full - 2007) Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

“CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.”

Since I know most of you are not going to dive into a medical study, here's a news article about the study-

Pot compound seen as tool against cancer (news – 2012) Pot compound seen as tool against cancer

“When McAllister and Desprez exposed the (“triple negative” breast cancer) cells to cannabidiol in a petri dish, the cells not only stopped acting "crazy" but they also started to revert to a normal state… The researchers stressed cannabidiol works only on cancer cells that have these high levels of ID-1 and these do not include all cancerous tumors but, rather, aggressive, metastatic cells. But they've found such high levels in leukemia, colorectal, pancreatic, lung, ovarian, brain and other cancers.”

And even if you have a non-ID1 cancer, CBD can still help by slowing the growth of the "feeder" blood vessels (angiogenesis), that cancer tricks your body into growing. The extra nourishment that these blood vessels bring to the tumor, speeds the cancer's growth! Prevent them from growing, and the cancer can't grow as fast!

Cannabidiol inhibits angiogenesis by multiple mechanisms. (full – 2012) Cannabidiol inhibits angiogenesis by multiple mechanisms

CBD also helps with some chemotherapy side effects.

Cannabidiol protects against doxorubicin-induced cardiomyopathy by modulating mitochondrial function and biogenesis. (full – 2015)
http://static.smallworldlabs.com/molmedcommunity/content/pdfstore/14_261_Hao.pdf

Single and combined effects of delta9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. (abst – 2017)
Single and combined effects of Δ9 -tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. - PubMed - NCBI



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