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New study- CBD vs colon cancer + 2 older studies

Discussion in 'Medical Marijuana Usage and Applications' started by Storm Crow, Mar 17, 2019.

  1. I really liked the last sentence of this study's abstract. CBD is described as a new "reliable anti-cancer drug". :yay:


    Cannabidiol-induced apoptosis is mediated by activation of Noxa in human colorectal cancer cells. (abst – 2019)
    https://www.sciencedirect.com/science/article/pii/S0304383519300230?via=ihub


    Highlights

    Our results strongly suggest, for the first time, that CBD can cause Noxa-induced cell death.


    CBD induced apoptotic cell death via ROS/Endoplasmic Reticulum stress-regulated Noxa activation in colorectal cancer cells.


    These results suggest that CBD has important implications for the potential treatment of human CRC.

    Abstract
    Cannabidiol (CBD), one of the compounds present in the marijuana plant, has anti-tumor properties, but its mechanism is not well known. This study aimed to evaluate the apoptotic action of CBD in colorectal cancer (CRC) cells, and focused on its effects on the novel pro-apoptotic Noxa-reactive oxygen species (ROS) signaling pathway. CBD experiments were performed using the CRC cell lines HCT116 and DLD-1. CBD induced apoptosis by regulating many pro- and anti-apoptotic proteins, of which Noxa showed significantly higher expression. To understand the relationship between Noxa and CBD-induced apoptosis, Noxa levels were downregulated using siRNA, and the expression of apoptosis markers decreased. After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents. As a result, CBD induced apoptosis in a Noxa-and-ROS-dependent manner. Taken together, the results obtained in this study re-demonstrated the effects of CBD treatment in vivo, thus confirming its role as a novel, reliable anticancer drug.



    FYI

    Apoptosis is one of the many ways a cell can die.

    Sirna is a way to "silence" a gene.

    And a little further reading on CBD and cancers- seems CBD can shut down the nasty ID-1 gene that makes some cancers so dang aggressive!

    Pot compound seen as tool against cancer (news – 2012) Pot compound seen as tool against cancer

    “When McAllister and Desprez exposed the (“triple negative” breast cancer) cells to cannabidiol in a petri dish, the cells not only stopped acting "crazy" but they also started to revert to a normal state… The researchers stressed cannabidiol works only on cancer cells that have these high levels of ID-1 and these do not include all cancerous tumors but, rather, aggressive, metastatic cells. But they've found such high levels in leukemia, colorectal, pancreatic, lung, ovarian, brain and other cancers."

    And the study that was based on-

    Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. (full - 2007) Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells

    “CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.”

    Also, CBD works in several ways to prevent the growth of "feeder blood vessels" (angiogenesis) that help a tumor grow faster than normal cells.

    Cannabidiol inhibits angiogenesis by multiple mechanisms. (full – 2012) Cannabidiol inhibits angiogenesis by multiple mechanisms



    Granny
     
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  2. @Storm Crow

    We knew it fought Cancer we just didn't know all the details of the how and why. :)
    Good read Granny.

    BNW
     
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  3. our endocannabinoid system is set up to defend against and defeat cancers. that is it spurpose to maintain cellular homeostasis via signalling... cancerous mass is not homeostasis @ all
     
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