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Need advice

Discussion in 'Medical Marijuana Usage and Applications' started by bkadams, Aug 30, 2012.

  1. So my grandfather suferers from Muscular scolosis(sp) and severe muscle spasms and has been going threw these episodes lately falling down numerous times a day.It has gotten far more severe recently then from when he began having these problems and finally having them diagnosed about a year ago.They have him on valium and a bunch of other meds and they recently asked him if he was interested in trying marijuana.

    Knowing him he's most likely against it but I really do think it will do wonders for him as going threw this much pain and constantly falling over he tends to get really depressed,no sleep so I think having marijuana would help every aspect.

    So what do you guys think?Any infortmation that would help me sit down and talk to him about it to try to get him to atleast give it a try would be muched appreciated.
     
  2. I have what you need! I am just going to give you a a fraction (and the most recent) of what I have collected. If you what the whole shebang, you have to send me an email! (bottom of my sig!) :D

    Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair! (news - 2010)
    Julie Falco brings hope to Multiple Sclerosis patients. Cannabinoids manage pain and promote repair! - National Cannabis Revolution | Examiner.com

    Nature's (Legal) Cannabinoids (news - 2010) US: Web: Nature's (Legal) Cannabinoids

    Marijuana and MS--an unfinished story. (news - 2010)
    Marijuana and MS--an unfinished story. - Free Online Library

    Weed Control Part 1: MS sufferer finds relief with medical marijuana
    (anecdotal/news - 2010)
    http://www.thestarphoenix.com/opini...ief+with+medical+marijuana/3198412/story.html

    Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors. (full – 2011)
    http://www.jneuroinflammation.com/content/pdf/1742-2094-8-102.pdf

    CANNABIDIOL INHIBITS PATHOGENIC T-CELLS, DECREASES SPINAL MICROGLIAL ACTIVATION AND AMELIORATES MULTIPLE SCLEROSIS-LIKE DISEASE IN C57BL/6 MICE. (full – 2011) Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice - Kozela - 2011 - British Journal of Pharmacology - Wiley Online Library

    Gadolinium-HU-308-incorporated micelles. (full – 2011)
    http://www.ncbi.nlm.nih.gov/books/NBK54067/pdf/CB2R-Gd-Micelles.pdf

    Emerging treatment options for spasticity in multiple sclerosis; clinical utility of cannabinoids (link to PDF – 2011) http://www.doaj.org/doaj?func=abstr...=or&q2=cannabis&f2=all&recNo=30&uiLanguage=en

    Acute and chronic cannabinoid extracts administration affects motor function in a CREAE model of multiple sclerosis. (abst – 2011) Acute and chronic cannabinoid extracts admi... [J Ethnopharmacol. 2011] - PubMed - NCBI

    Role of cannabinoids in multiple sclerosis (abst – 2011)
    Role of cannabinoids in multiple sclerosis. [CNS Drugs. 2011] - PubMed - NCBI

    Inhibitory Effect of Standardized Cannabis sativa Extract and Its Ingredient Cannabidiol on Rat and Human Bladder Contractility. (abst – 2011) Inhibitory effect of standardized cannabis sativa ex... [Urology. 2011] - PubMed - NCBI

    Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis. (abst – 2011)
    Unbound MEDLINE | Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis. PubMed Journal article

    A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. (abst – 2011)
    Clinical Studies and Case Reports

    Treating pain in multiple sclerosis. (abst – 2011) Treating pain in multiple sclerosis. [Expert Opin Pharmacother. 2011] - PubMed - NCBI

    THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis. (abst - 2011)
    Unbound MEDLINE | THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis. PubMed Journal article abstract

    New metabolic pathway for controlling brain inflammation (news – 2011)
    New metabolic pathway for controlling brain inflammation

    The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α (full – 2012) The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-

    Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial. (full – 2012) Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

    Cannabinoids ameliorate disease progression in a model of multiple sclerosis in mice, acting preferentially through CB(1) receptor-mediated anti-inflammatory effects.
    (abst - 2012) Cannabinoids ameliorate disease progressio... [Neuropharmacology. 2012] - PubMed - NCBI

    The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α (abst – 2012) The Synthetic Cannabinoid R(+)WIN55,212-2 Augmen... [J Biol Chem. 2012] - PubMed - NCBI

    Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9 (abst – 2012)
    Cannabinoid receptor 2 agonists inhibit migration of activated dendritic cells via modulation of MMP-9 -- Adhikary et al. 188 (1001): 173.23 -- The Journal of Immunology

    A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine. (abst – 2012) A questionnaire survey of patients ... [Prim Health Care Res Dev. 2012] - PubMed - NCBI

    Potential Control of Multiple Sclerosis by Cannabis and the Endocannabinoid System.
    (abst – 2012) Potential control of multiple... [CNS Neurol Disord Drug Targets. 2012] - PubMed - NCBI

    Evaluation of the safety and tolerability profile of Sativex: is it reassuring enough?
    (abst – 2012) Evaluation of the safety and tolerabili... [Expert Rev Neurother. 2012] - PubMed - NCBI

    Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity. (abst – 2012)
    Clinical efficacy and effectiveness of ... [Expert Rev Neurother. 2012] - PubMed - NCBI

    Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial. (abst – 2012)
    MUltiple Sclerosis and Extract... [J Neurol Neurosurg Psychiatry. 2012] - PubMed - NCBI



    Hope to hear from you soon!



    Granny :wave:
     

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