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Mouse study- Cannabis Roots vs Diabetes

Discussion in 'Medical Cannabis: Treatments & Patient Experiences' started by Storm Crow, May 16, 2023.

  1. #1 Storm Crow, May 16, 2023
    Last edited: May 16, 2023
    Cannabis roots are often overlooked as a source of healing compounds because they have only traces of THC and CBD. But there is a lot more to cannabis than just THC and CBD. And every now and then, someone takes a closer look at cannabis roots can do and gets a surprise. In this study they found that extracts from hemp roots can protect against diabetes.
    My translations/comments are in parentheses, italics and (bolded). Link leads to the full study.


    Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice. (Korea) (full – 2023) Protective Effects of Hemp (Cannabis sativa) Root Extracts against Insulin-Deficient Diabetes Mellitus In Mice

    The pharmacological potential of industrial hemp (Cannabis sativa) has been widely studied. However, the majority of studies have focused on cannabidiol, isolated from the inflorescence and leaf of the plant.
    (inflorescence = flowers)

    In the present study, we evaluated the anti-diabetic potential of hemp root water (HWE) and ethanol extracts (HEE) in streptozotocin (STZ)-induced insulin-deficient diabetic mice.
    (So we gave the mice diabetes with a chemo drug, streptozotocin, then gave them either a water- or alcohol hemp root extract.)

    The administration of HWE and HEE ameliorated hyperglycemia and improved glucose homeostasis and islet function in STZ-treated mice (p < 0.05).
    (Giving the mice the extracts helped to lower their blood sugar, and improved islet function - the islets are pancreatic cells that secrete insulin.)

    HWE and HEE suppressed β-cell apoptosis and cytokine-induced inflammatory signaling in the pancreas (p < 0.05).
    (Both extracts prevented β-cells from dying (apoptosis) and reduced inflammation caused by pro-inflammatory cytokines in the pancreas.)

    Moreover, HWE and HEE normalized insulin-signaling defects in skeletal muscles and apoptotic response in the liver and kidney induced by STZ (p < 0.05).
    (Also, both extracts normalized the way that insulin signals muscles store protein, and they reduced cell death in the liver and kidneys caused by the streptozotocin.)

    Gas chromatography-mass spectrometry analysis of HWE and HEE showed possible active compounds which might be responsible for the observed anti-diabetic potential.
    (We tested for the active compounds that might be causing these effects.)

    These findings indicate the possible mechanisms by which hemp root extracts protect mice against insulin-deficient diabetes, and support the need for further studies geared towards the application of hemp root as a novel bioactive material.
    (So we think we have found out how hemp root extracts can protect mice against diabetes, but we need more money to look into this.)




    So those roots we throw away, may, eventually, be just as important as the buds! :eek2:

    Granny :wave:
     
    • Winner Winner x 4
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  2. #2 BrassNwood, May 16, 2023
    Excellent info as always..

    BNW
     
    • Like Like x 1
  3. #3 Headhunterpipes, May 16, 2023
    Been using roots for meds for years. smoothies and as a tea
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  4. #4 akkeosflomdis, Jun 17, 2023
    Wow, that's really fascinating! It's amazing to think that cannabis roots, which are often overlooked, could have such potential healing properties. It's true that we tend to focus on THC and CBD when it comes to cannabis, but this study shows that there's so much more to explore. The fact that hemp root extracts were able to protect mice against insulin-deficient diabetes is truly promising. It's interesting to see that the extracts not only improved glucose regulation and islet function but also prevented cell death and reduced inflammation in various organs. This research suggests that there are active compounds in the hemp roots that are responsible for these beneficial effects. It's definitely worth further investigation and could potentially lead to the development of new bioactive materials. It just goes to show that we shouldn't underestimate the potential of different parts of plants and how they can contribute to our well-being. Who knew those discarded roots could be so important? It's definitely something to keep an eye on as more studies unfold!
     
    • Agree Agree x 1
  5. #5 ThePhantom, Aug 9, 2023
    I've only heard rare instances of using cannabis roots in the past, but those cases all seemed to be exceptionally positive. To think that so much of the cannabis plant is being wasted with each harvest!
     
    • Agree Agree x 1

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