Dismiss Notice
Food and Drug Administration (FDA) Disclosure:

The statements in this forum have not been evaluated by the Food and Drug Administration and are generated by non-professional writers. Any products described are not intended to diagnose, treat, cure, or prevent any disease.

Website Disclosure:

This forum contains general information about diet, health and nutrition. The information is not advice and is not a substitute for advice from a healthcare professional.

Marijuana and epilepsy questions

Discussion in 'Medical Cannabis: Treatments & Patient Experiences' started by abs1337, Jul 28, 2013.

  1. #1 abs1337, Jul 28, 2013
    Hi,
     
    I have a form of epilepsy where I get seizures in the form in sleep paralysis. I was on Levetiracetam for over 2 years, and have been seizure(sleep paralysis) free for almost a year how, which is also the same time I stopped my meds, and started smoking marijuana - not immediately, but over a duration of 2 months or so.
     
    I only ever smoked for recreational purposes. I've been smoking regularly for the past year, with only a few 1 week breaks in between, never longer. I'm currently on a month long break (18/29 days) because of Ramadan, and also I figured I'd get my tolerance down.
     
    I had my first sleep paralysis episode in over a year 2 days ago, and then another today... the only 2 things that have changed over the past year (since I stopped my meds) was my sleep schedule is currently very messed up due to Ramadan (I sleep like 3 hours, then a 2 hour gap for breakfast, and then 4-5 more hours, with an occasional nap in the day) - my doctor did warn me about keeping a strict sleep schedule (he wanted me to sleep at least 8 hours non stop and no naps in the day). And the other thing was the break I'm taking from marijuana.
     
    I can't help but think that maybe it was marijuana that was actually helping me with my sleep paralysis. My sleep schedule was better in the past year than it currently is, but I still had a bad sleep schedule since I work in the IT industry, though I was getting at least 6-7 hours of sleep on average.
     
    I guess I'm looking for someone who can help me understand this and the effects of medical marijuana with epilepsy. For now, I'm going go score tomorrow, and I will have to continue this sleep schedule for 11 more days.
     
    Also I've been smoking only Indiacas.. and we don't get anything else in India.
     
    Thanks.

     
  2. #2 LAMedicate, Jul 28, 2013
    I believe studies have shown it helps, granny storm crow will probably post here shortly with a bunch of informative links hahaha
     
  3. #3 abs1337, Jul 30, 2013
    so miss granny storm crow, any help?
     
    Thanks.
     
  4. #4 Storm Crow, Jul 30, 2013
    Here's what I have on epilepsy and cannabinoids for just the last 5 years. Cannabis has been used for epilepsy for a LONG time! (start by reading just the news articles.)
     
    The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.        (full – 2008)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2438968/?tool=pubmed
     
    The cannabinoid anticonvulsant effect on pentylenetetrazole-induced seizure is potentiated by ultra-low dose naltrexone in mice       (abst – 2008)  http://www.ncbi.nlm.nih.gov/pubmed/18502613
     
    The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats.     
    (full – 2009)        http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2009.02098.x/full
     
    Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.           (full – 2009)  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757117/?tool=pubmed
     
    Effect of arachidonyl-2'-chloroethylamide, a selective cannabinoid CB1 receptor agonist, on the protective action of the various antiepileptic drugs in the mouse maximal electroshock-induced seizure model.         (abst – 2009)   http://www.ncbi.nlm.nih.gov/pubmed/19751793
     
    Involvement of nitrergic system in the anticonvulsant effect of the cannabinoid CB(1) agonist ACEA in the pentylenetetrazole-induced seizure in mice.       (abst – 2009)   http://www.ncbi.nlm.nih.gov/pubmed/19223154
     
    Medical Marijuana and Epilepsy      (news – 2009)
    https://www.marijuanadoctors.com/content/ailments/view/79?ailment=epilepsy
     
    Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo      (full - 2010)       http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831/?tool=pmcentrez
     
    Cannabinoid-mediated inhibition of recurrent excitatory circuitry in the dentate gyrus in a mouse model of temporal lobe epilepsy.      (full – 2010)
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782/?tool=pubmed
     
    AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.       (full – 2010)
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006205/?tool=pubmed
     
    Delta-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats.        (abst - 2010)          http://www.ncbi.nlm.nih.gov/pubmed/20196794
     
    Anticonvulsant effects of GWP42006 in vitro and in vivo in rat       (abst - 2010)
    http://www.physoc.org/proceedings/abstract/Proc%20Physiol%20Soc%2019C117
     
    Dynamic changes of CB1-receptor expression in hippocampi of epileptic mice and humans.      (abst – 2010)        http://www.ncbi.nlm.nih.gov/pubmed/20618415
     
    Endocannabinoid system protects against cryptogenic seizures.      (full – 2011)
    http://www.if-pan.krakow.pl/pjp/pdf/2011/1_165.pdf
     
    Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy           (full – 2011)    
    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027196
     
    Convulsions Associated with the Use of a Synthetic Cannabinoid Product.    (full – 2011)
    http://www.springerlink.com/content/9651q2672027n38g/fulltext.html
     
    Pro-epileptic effects of the cannabinoid receptor antagonist SR141716 in a model of audiogenic epilepsy.      (abst – 2011)       http://www.ncbi.nlm.nih.gov/pubmed/21733658
     
    Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.    (abst – 2011)
    http://www.unboundmedicine.com/medline/ebm/record/21238473/abstract/Synthetic_cannabinoid_WIN_55212_2_mesylate_enhances_the_protective_action_of_four_classical_antiepileptic_drugs_against_maximal_electroshock_induced_seizures_in_mice_
     
    Protective effects of CB1 receptor agonist WIN 55.212-2 in seizure activity in the model of temporal lobe epilepsy         (abst – 2011)
    http://www.unboundmedicine.com/medline/ebm/record/21469332/abstract/%5BProtective_effects_of_CB1_receptor_agonist_WIN_55_212_2_in_seizure_activity_in_the_model_of_temporal_lobe_epilepsy%5D_
     
    L-Type Calcium Channel Mediates Anticonvulsant Effect of Cannabinoids in Acute and Chronic Murine Models of Seizure.        (abst – 2011)  http://www.ncbi.nlm.nih.gov/pubmed/21928146
     
    Changes in the cannabinoid (CB1) receptor expression level and G-protein activation in kainic acid induced seizures.      (abst – 2011)      http://www.ncbi.nlm.nih.gov/pubmed/22079489
     
    In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.      (abst – 2011)        http://www.ncbi.nlm.nih.gov/pubmed/21303859
     
    Marijuana, endocannabinoids, and epilepsy: Potential and challenges for improved therapeutic intervention.      (abst - 2011)        http://www.ncbi.nlm.nih.gov/pubmed/22178327
     
    Cannabis could help treat epilepsy        (news – 2011)  http://www.newkerala.com/news/world/fullnews-186693.html
     
    Cannabis could be used to treat epilepsy        (news – 2011)
    http://www.telegraph.co.uk/science/science-news/8440303/Cannabis-could-be-used-to-treat-epilepsy.html
     
    New research provides hope for those with epilepsy     (news - 2011) 
    http://medicalxpress.com/news/2011-04-epilepsy.html
     
    Neuron to Astrocyte Communication via Cannabinoid Receptors Is Necessary for Sustained Epileptiform Activity in Rat Hippocampus       (full – 2012) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037320
     
    Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models.
    (full – 2012)     http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02207.x/full    
     
    Cannabidivarin is anticonvulsant in mouse and rat.       (full – 2012)
    http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2012.02207.x/pdf
     
    Use of the phytocannabinoid cannabidivarin (cbdv) in the treatment of epilepsy: Patent Application 20120004251         (full – 2012)
    http://www.freshpatents.com/-dt20120105ptan20120004251.php
     
    Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period.       (abst – 2012)  http://www.ncbi.nlm.nih.gov/pubmed/22019959
     
    Equipotent Inhibition of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase - Dual Targets of the Endocannabinoid System to Protect against Seizure Pathology.
    (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22270809
     
    Epileptiform activity in the CA1 region of the hippocampus becomes refractory to attenuation by cannabinoids in part because of endogenous γ-aminobutyric acid type B receptor activity.        (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22388975
     
    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?        (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22625422
     
    Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
    (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22509801
     
    Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.        (abst – 2012)         http://www.ncbi.nlm.nih.gov/pubmed/22520455
     
    Internet Highs-Seizures After Consumption of Synthetic Cannabinoids Purchased Online.
    (abst – 2012)        http://www.ncbi.nlm.nih.gov/pubmed/22824736
     
    Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.      (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/22504215
     
    Effect of ACEA-a selective cannabinoid CB1 receptor agonist on the protective action of different antiepileptic drugs in the mouse pentylenetetrazole-induced seizure model.
    (abst – 2012)          http://www.ncbi.nlm.nih.gov/pubmed/22789660
     
    First European case of convulsions related to analytically confirmed use of the synthetic cannabinoid receptor agonist AM-2201.        (abst – 2012)   http://www.ncbi.nlm.nih.gov/pubmed/22936123
     
    Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.
    (abst – 2012)       http://www.ncbi.nlm.nih.gov/pubmed/23159379
     
    Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.         (abst – 2012)
    http://www.ncbi.nlm.nih.gov/pubmed/23206503
     
    Inverse relationship of cannabimimetic (R+)WIN 55, 212 on behavior and seizure threshold during the juvenile period           (abst – 2012)  
    http://www.ncbi.nlm.nih.gov/pubmed/22019959   
     
    Science/UK: Antiepileptic efficacy of cannabidivarin will be tested in clinical studies
    (news – 2012)     
    http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=382
     
    'Hammer Head' 'incense' blamed for seizure of youth in Le Roy      (news – 2012)
    http://thebatavian.com/howard-owens/hammer-head-incense-blamed-seizure-youth-le-roy/29983
     
    How Medical Marijuana Is Giving a Six-Year-Old Boy New Life         (news – 2012)
    http://thinkprogress.org/justice/2012/09/18/854811/how-medical-marijuana-is-giving-a-six-year-old-boy-new-life/?mobile=nc
     
    Cannabis and other illicit drug use in epilepsy patients.       (abst – 2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23311572
     
    The Role of CB1-Receptors in the Proconvulsant Effect of Leptin on Penicillin-Induced Epileptiform Activity in Rats.     (abst – 2013)    http://www.ncbi.nlm.nih.gov/pubmed/23521910
     
    The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice.       (abst – 2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23644464
     
    Cannabinoid 1 receptor as therapeutic target in preventing chronic epilepsy  
    (abst – 2013)    http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/660.2?sid=eea722c0-971c-4daa-8b8c-38c0c63c19ad
     
    The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling.            (abst – 2013)    http://www.ncbi.nlm.nih.gov/pubmed/23732642
     
    The role of α2-adrenoceptors in the anti-convulsant effects of cannabinoids on pentylenetetrazole-induced seizure threshold in mice.        (abst – 2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23756131
     
    CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations.        (abst – 2013)
    http://www.ncbi.nlm.nih.gov/pubmed/23860329
     
    Science/Animal: CBD inhibits the activity of a certain liver enzyme    (news – 2013)
    http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=391&search_pattern=2013#10
     
    Cannabis Anti-Convulsant Shakes up Epilepsy Treatment     (news – 2013)
    http://www.thecompassionchronicles.com/2013/01/26/cannabis-anti-convulsant-shakes-up-epilepsy-treatment/
     
    New cannabis discovery could lead to better treatments for epilepsy     (news – 2013)
    http://www.reading.ac.uk/news-and-events/releases/PR464765.aspx
     
    Parents of epileptic N.J. tot lament medical marijuana delays            (news – 2013) http://articles.philly.com/2013-06-24/news/40148313_1_marijuana-law-marijuana-card-dispensary
     
    Medical Marijuana for Kids? Some Praise Results While Others Worry About Risks
    (news – 2013)         http://www.cnbc.com/id/100876423
     
    New therapy for fragile X chromosome syndrome discovered   (news – 2013) http://www.sciencecodex.com/new_therapy_for_fragile_x_chromosome_syndrome_discovered-110170
     
    Charlotte's Web Of Suffering: Six-Year-Old Colorado Girl With Dravet Syndrome Finds Relief From Marijuana High In CBD         (news – 2013) http://www.marijuana.com/news/2013/06/charlottes-web-of-suffering-six-year-old-colorado-girl-with-dravet-syndrome-finds-relief-from-marijuana-high-in-cbd/
     
    Toronto family hopes for access to controversial treatment to cure baby's rare epilepsy
    (news – 2013)    
    http://globalnews.ca/news/714104/toronto-family-hopes-for-access-to-controversial-treatment-to-cure-babys-rare-epilepsy/
     
    New Study: Cannabinoids Protect the Brain and Heart From Injury        (news – 2013)
    http://jewishbusinessnews.com/2013/06/09/new-study-cannabinoids-protect-the-brain-and-heart-from-injury/
     
    And a little more-
     
    [SIZE=12pt]Ayurvedic Herbs – Cannabis       (article – undated)  [/SIZE]http://www.indianmirror.com/ayurveda/cannabis.html
    \n[SIZE=12pt]The Religious and Medicinal Uses of Cannabis in China, India and Tibet    (full - 1981)[/SIZE]
    http://www.cnsproductions.com/pdf/Touw.pdf
    \n[SIZE=12pt]Cannabis in Traditional Indian Herbal Medicine       (full - 2001)[/SIZE]
    http://www.ucl.ac.uk/~ucgadkw/papers/cannabis.pdf
    \n[SIZE=12pt]Indigenous Uses and Ethnobotany of Cannabis sativa L. (Hemp) in Uttaranchal (India)      (link to PDF - 2004)[/SIZE]
    http://www.informaworld.com/smpp/content~db=all?content=10.1300/J237v09n01_07
    \n[SIZE=12pt]Cannabis in India: ancient lore and modern  medicine      (full - 2005)[/SIZE]
    http://www.drugpolicy.org/docUploads/Russo_CannabisInIndia_Mechoulam2005.pdf
    \nHope that helps!
    \nGranny
     
  5. #5 abs1337, Aug 1, 2013
    ^ Whoa!!

    Thanks a lot! Going through them!
     

Share This Page