I Told You So

I sent a picture of this to my daughter. Her hubby is going bald!

 

Is that the reason why I kept forgetting to take my anti-depressants when I was taking CBD gummies?

 

a quick link to a page with Cannabinoid info explaining the biochemical pathways
Medicalbiochemistrypage -endocannabinoids
Endocannabinoids in Feeding Behavior and Energy Homeostasis

 

Did THE DONALD do that combover? Transplant the hairs from my ears, eyebrows & nose, that shit grows like crazy.

 

Yeah it is quite complex and who has got it right so far is unknown as the GOV still blocks the research and the biochemistry to keep people down in the dirt and not knowing anything ...
CBD is active mostly in CB2 as an negative allosteric modulator, a cb2 Antagonist ... CBD metabolism increases intracellular enzymes ( Epoxides and Fatty acid binding proteins ) that serve to biodegrade the lipid via lipid signaling ...
with enough CBD in circulation CBD can back cross talk to cb1 via lipid rafts and Cytokines .
all of the metabolism of phytocannabinoids are non selective as compared to endocannabinoids that are Selective and can select for cb receptors etc....
that medical biochemistry page gets it close but not exact ...
Edit - another consideration not usually considered when doing CBD research = Chirality ! CBD can dock into cb receptors at any given moment in about 4 different ways depending on how CBD Xpresses when engaging with the cb receptors . as a three D shape the 4 sides are a bit differnet

 

A couple on lung cancer-

Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. (UK) (full – 2019) Striking lung cancer response to self-administration of cannabidiol: A case report and literature review

In spite of new drugs, lung cancer is associated with a very poor prognosis. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during follow-up. Thus, new drugs or re-evaluation of existing therapies used to treat other non-malignant diseases (drug repurposing) are still needed. While this research both in vitro and in vivo is being carried out, it is important to be attentive to patients where the disease responds to treatments not considered standard in clinical practice. We report here a patient with adenocarcinoma of the lung who, after declining chemotherapy and radiotherapy, presented with tumour response following self-administration of cannabidiol, a non-psychoactive compound present in Cannabis sativa. Prior work has shown that cannabidiol may have anti-neoplastic properties and enhance the immune response to cancer. The data presented here indicate that cannabidiol might have led to a striking response in a patient with lung cancer.

That the scientists used the word "striking" in the title, is very unusual. I think their minds were blown!


Inhalant cannabidiol impedes tumor growth through decreased tumor stemness and impaired angiogenic switch in NCI-H1437-induced human lung cancer model. (USA/ Belgium) (abst – 2023) https://link.springer.com/article/10.1007/s13577-023-00869-8

Lung cancer remains the most chronic form of cancer and the leading cause of cancer mortality in the world. Despite significant improvements in the treatment of lung cancer, the current therapeutic interventions are only partially effective, necessitating the continued search for better, novel alternative treatments. Angiogenesis and cancer stem cells play a central role in the initiation and propagation of cancers. Tumor angiogenesis is triggered by an angiogenic switch when pro-angiogenic factors exceed anti-angiogenic components. Although many anti-angiogenic agents are used in cancer treatment, there are therapeutic limitations with significant side effects. In recent years, cannabinoids have been investigated extensively for their potential anti-neoplastic effects. Our previous findings showed that cannabidiol (CBD) could impede tumor growth in mouse models of melanoma and glioblastoma. Importantly, CBD has been suggested to possess anti-angiogenic activity. In this study, we tested, for the first time, inhalant CBD in the treatment of heterotopic lung cancer and whether such potential effects could reduce cancer stem cell numbers and inhibit tumor angiogenesis. We implanted NCI H1437 human lung cancer cells in nude mice and treated the mice with inhalant CBD or placebo. The outcomes were measured by tumor size and imaging, as well as by immunohistochemistry and flow cytometric analysis for CD44, VEGF, and P-selectin. Our findings showed that CBD decreased tumor growth rate and suppressed expression of CD44 and the angiogenic factors VEGF and P-selectin. These results suggest, for the first time, that inhalant CBD can impede lung cancer growth by suppressing CD44 and angiogenesis.

Granny

 

And breast cancer. The ID-1 gene makes cancers more aggressive and harder to treat. CBD "defuses" the ID-1 gene! This had been discovered in 2007 and then was forgotten.

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. (full - 2007) https://mct.aacrjournals.org/content/6/11/2921.long
Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers. Using a mouse model, we previously determined that metastatic breast cancer cells became significantly less invasive in vitro and less metastatic in vivo when Id-1 was down-regulated by stable transduction with antisense Id-1. It is not possible at this point, however, to use antisense technology to reduce Id-1 expression in patients with metastatic breast cancer. Here, we report that cannabidiol (CBD), a cannabinoid with a low-toxicity profile, could down-regulate Id-1 expression in aggressive human breast cancer cells. The CBD concentrations effective at inhibiting Id-1 expression correlated with those used to inhibit the proliferative and invasive phenotype of breast cancer cells. CBD was able to inhibit Id-1 expression at the mRNA and protein level in a concentration-dependent fashion. These effects seemed to occur as the result of an inhibition of the Id-1 gene at the promoter level. Importantly, CBD did not inhibit invasiveness in cells that ectopically expressed Id-1. In conclusion, CBD represents the first nontoxic exogenous agent that can significantly decrease Id-1 expression in metastatic breast cancer cells leading to the down-regulation of tumor aggressiveness.


In 2012, some reporters stumbled across that study and reported it as Pot compound seen as tool against cancer (news – 2012) Pot compound seen as tool against cancer Just an excerpt from the article-

“When McAllister and Desprez exposed the (“triple negative” breast cancer) cells to cannabidiol in a petri dish, the cells not only stopped acting "crazy" but they also started to revert to a normal state… The researchers stressed cannabidiol works only on cancer cells that have these high levels of ID-1 and these do not include all cancerous tumors but, rather, aggressive, metastatic cells. But they've found such high levels in leukemia, colorectal, pancreatic, lung, ovarian, brain and other cancers.”


FIFTEEN YEARS later ( ), the long-forgotten McAllister/Desprez study was repeated with the same amazing results! The cells stopped acting "crazy" and they also reverted to a normal state!

CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β (full – 2020) CBD Reverts the Mesenchymal Invasive Phenotype of Breast Cancer Cells Induced by the Inflammatory Cytokine IL-1β

Cannabidiol (CBD) has been used to treat a variety of cancers and inflammatory conditions with controversial results. In previous work, we have shown that breast cancer MCF-7 cells, selected by their response to inflammatory IL-1β cytokine, acquire a malignant phenotype (6D cells) through an epithelial–mesenchymal transition (EMT). We evaluated CBD as a potential inhibitor of this transition and inducer of reversion to a non-invasive phenotype. It decreased 6D cell viability, downregulating expression of receptor CB1. The CBD blocked migration and progression of the IL-1β-induced signaling pathway IL-1β/IL-1RI/β-catenin, the driver of EMT. Cannabidiol reestablished the epithelial organization lost by dispersion of the cells and re-localized E-cadherin and β-catenin at the adherens junctions. It also prevented β-catenin nuclear translocation and decreased over-expression of genes for ∆Np63α, BIRC3, and ID1 proteins, induced by IL-1β for acquisition of malignant features. Cannabidiol inhibited the protein kinase B (AKT) activation, a crucial effector in the IL-1β/IL-1RI/β-catenin pathway, indicating that at this point there is crosstalk between IL-1β and CBD signaling which results in phenotype reversion. Our 6D cell system allowed step-by-step analysis of the phenotype transition and better understanding of mechanisms by which CBD blocks and reverts the effects of inflammatory IL-1β in the EMT.

The cancer cells reverted to what appeared to be normal cells! How's that for a total mind-blower?

Chemotherapy poisons the cancer, and the doctors are hoping that the cancer will die before you do! But if you do chose chemotherapy, CBD and other cannabinoids may help your chemotherapy work better. (This is a quote from the study, not the abstract.)

The Antitumor Activity of Plant-Derived Non- Psychoactive Cannabinoids
The antitumor activity of plant-derived non-psychoactive cannabinoids

"CBD however does not produce the psychotropic effects and has a low toxicity profile, therefore, using moderate to high doses of the drug is potentially feasible..... “Cannabinoids however also sensitize, and in some cases resensitize, tumors to first-line agents. A cannabinoid drug treatment with a low toxicity profile that together produces direct antitumor activity and sensitizes tumors to existing first-line agents is an attractive therapeutic modality."

CBD is under appreciated!

Granny

 

Thank you for the info. I'm seriously thinking about gathering up all the scientific data I can find and renting a Ryder truck and taking it to Indianapolis to the Indiana General Assembly and dropping the whole thing in the legislature and saying, "Here are your studies you wanted." Now at least legalize medical. Some people can't take opiates for pain.

 

Oh, I can be very BLUNT!!! That is why my kids think I have Alzheimer's, I don't have a filter for my mouth. I just realized, what little my parents stuck up for me when I was little, no one is here to do that now. All of my life I let people push me around and I'm sick of it. Now I feel like I should be doing that all along. I just keep kicking myself in the ass for trusting my children when they said, "Don't worry, Mom. You can drive one of our cars. We don't have room for a third car." Now she realizes that she is going to have to get a 3rd car because her daughter is going to be driving next year. And she gets the Camry Hybrid to drive to college. And her daughter thinks that her aunt is going to let her live with her. That's funny. My other daughter made it known to me that she doesn't want anyone to live with her. My kids are both college graduates, but there are other ways your kids can hurt and disappoint you.

 

@OrionM42 Way back when the List was just under 500 pages, a guy did just that- printed up the whole thing and showed it to everyone at Hempfest! He said it made a very satisfying "thump" when he dropped it on a table and it opened a few eyes to the fact that there are a lot of studies on cannabis.

Granny