OK, it's that time of year again- the new List is almost ready to be sent out. So I have written an new introduction for the January 2014 List. I need you guys to critique it! Did I screw up a verb tense? Do a run-on sentence? Misspell a word? Is a sentence clumsy or awkward? [SIZE=12pt]My Goodness! How my List has grown over the last few months! And there have been some rather unexpected new â€œbranchingsâ€ in the List recently. Acetaminophen, black tea, flax, echinacea and magnolias? How did they manage to sneak into my list on cannabis, cannabinoids, and the endocannabinoid system? [/SIZE] [SIZE=12pt]The answer is simple, the plants all contain compounds that interact with receptors in the endocannabinoid system. Science has discovered that cannabinoids are, indeed, made by other plants. So far, none of them cause the same dramatic psychoactive CB1 receptor reaction (the high) as THC. They seem to be mostly limited to the CB2 receptors (no high, just healing). [/SIZE] [SIZE=12pt]Acetaminophen, on the other hand, is transformed by your body into a compound called AM-404, which blocks the break-down of anandamide, your body's own version of THC. Just like THC, anandamide makes you â€œfeel goodâ€ and decreases pain. Blocking the break-down of the fragile anandamide by AM-404 results in more anandamide being in your body, relieving your pain. The acetaminophen, itself, does nothing to relieve your pain! [/SIZE] [SIZE=12pt]As much as I would like it to be, cannabis is not 100% safe- nothing is! There is something you need to understand about the endocannabinoid system- it is a system of checks and balances. The amounts of endocannabinoids vary according to the body's needs. As an example, during a woman's ovulation, her anandamide levels spike, then drop drastically for the implantation of the egg. THC during ovulation would have little effect, but just days later, THC might interfere with implantation. Women trying to get pregnant should avoid cannabis.[/SIZE] [SIZE=12pt]Teens under the age of 16 should not be using cannabis unless there is a medical reason. The adolescent brain undergoes a â€œrewiring jobâ€ and the endocannabinoid system is right in the middle of things. The fear is that THC will cause â€œmisconnectionsâ€ resulting in subtle personality changes or neurosis. Like alcohol, cannabis should normally be reserved for adults. [/SIZE] [SIZE=12pt]Likewise, cancer is not just one disease, which is why one treatment does not work on all types of cancer. Most cancers appear to be slowed by THC, but there are a few rare exceptions. When exposed to THC or similar synthetics, A549 lung cancer cells start reproducing, while exposure to CBD slows them down*. The usual â€œhigh THCâ€ RSO could be a disaster for a small minority of cancer patients. We need more research, but that can't happen without legalization! [/SIZE] [SIZE=12pt]Our government has lied to us about the effects of cannabis for over seven decades. They have blocked virtually all research into cannabis and how it heals. They have ranked a never-fatal herbal medicine with the most deadly kinds of drugs, against all scientific evidence! Yet, somehow that inconvenient truth keeps coming out - cannabis heals! It is time that we, as a nation, demand that the truth be openly acknowledged and research into this amazing plant begun! As my Grandfather said, â€œIf the truth won't do, then something is wrong! [/SIZE] [SIZE=12pt]*[/SIZE][SIZE=8pt] Critical appraisal of the potential use of cannabinoids in cancer management. (link to PDF â€“ 2013) [/SIZE][SIZE=8pt]http://www.dovepress.com/critical-appraisal-of-the-potential-use-of-cannabinoids-in-cancer-mana-a14216[/SIZE] OK- have at it!