This is just a thought, like a total "maybe?" I dont even believe this, I just thought it was a reasonable argument to consider. I will not argue or even begin to argue that marijuana IS and always will be a plant and in that aspect natural. It's just that the fact that in nature everything seems to be balanced naturally and we as humans always try to develop our own way and the outcome is not always good. For example if you add a new strain of plant to an ecosystem things can go very unbalanced, this being an unlikely but still possible situation, or maybe it will do no harm at all. The strains that have been created by nature are plants that have been developed by the original cannabis plant being secluded in a specific climate and area and acquiring specific trates to fit its exact needs and natures balance. Something I learned about in Bio but I'm not completely sure about the correct name, so someone let me know what its called if you know. Like when the same plant develop in different secluded areas they slowly begin to change and adapt, but will still be considered the same genetics, and will still be compatible. Similar to if two of the same kind of lizard was separated and secluded over long periods of time they would acquire different trates, but still be able to mate if ever met again. Anyway to the point: We have taken these strains that naturally developed over thousands of years like strains from India, Russia, Mexico, etc and created own own versions that may not have been possible to happen in nature. There for in that aspect not natural. When I say natural I'm meaning in nature with little human contact, but then again we could be considered part of nature. What I'm saying is many of these high THC, while low in CBD and CBN plants or plants of any other order and combinations of Cannabinoids may not have occurred as they are in nature itself. - Could this be dangerous over long periods of time? I dunno probably not I dont think but its just something to consider. I know I did not use proper terms most likely but its just the general idea, I'm not a scientist! But I know smoking a huge bowl of kief or hash is different considering all the cannabinoids are not in the same balance. Many cannabinoids counter effect a more head high that a deep sativa can give you, and keeps you calm. Maybe someone has had a panic attack from smoking a heavy sativa based plant's THC in huge amounts at once and can relate. Anyway happy toking!