Seems that they found 2 CBD derivatives that can increase the effectiveness of Naloxone. Since they talk about other drugs in this article, I'm just snipping out the interesting part on the CBC derivative. Marijuana-derived compounds could reverse opioid overdoses https://medicalxpress.com/news/2023-03-marijuana-derived-compounds-reverse-opioid-overdoses.html Earlier research suggesting that CBD can interfere with opioid binding inspired the current effort. In research published in 2006, a group based in Germany concluded that CBD hampered opioid binding indirectly, by altering the shape of the receptor. When used with naloxone, they found CBD accelerated the medication's effect, forcing the receptors to release opioids. To augment these effects, Gudorf altered CBD's structure to generate derivatives. Taryn Bosquez-Berger, a graduate student in Straiker's group, tested these new compounds in cells with a substance called DAMGO, an opioid used only in lab studies. To measure their success, she monitored a molecular signal that diminishes when this type of drug binds. Armed with feedback from these experiments, Gudorf refined the structures she generated. In the end, they narrowed the field to 15, which they tested at varying concentrations against fentanyl, with and without naloxone. Several derivatives could reduce fentanyl binding even at what Bosquez-Berger described as "incredibly low" concentrations, while also outperforming naloxone's opioid-blocking performance. Two of these also showed a synergistic effect when combined with the antidote. Granny
To much of it and it completely blocks the THC. I had to wait 6 hours in pain before the damned effects wore down enough to allow the THC to start kicking ass again. A tiny touch (what is in most strains naturally) is good as it takes the really sharp edge off pure THC but to much and.... I've grown out high CBD plants on request and it didn't take but a couple of tests to be sure but damn. Ruined my day.. I Hate pain. THC good... CBD bad. Whatever the THC is doing to unlock the surgical adhesions in my belly the CBD totally interferes with. BNW