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Cannabidiol enhances the effects of THC on brain cancer cells

Discussion in 'Medical Marijuana Usage and Applications' started by Poisongage, Jan 25, 2010.

  1. #1 Poisongage, Jan 25, 2010
    Last edited by a moderator: Jan 26, 2010
    From the IACM bulletin, 17th January 2010:

    http://www.cannabis-med.org/english/bulletin/ww_en_db_cannabis_artikel.php?id=313#3

    Science: Cannabidiol enhances the anti-cancer effects of THC on
    human brain cancer cells

    According to research at the California Pacific Medical Center
    Research Institute in San Francisco cannabidiol (CBD) increased
    the inhibitory effects of dronabinol (THC) on human brain cancer
    cell proliferation and survival. The two natural cannabinoids were
    tested on two glioblastoma cells lines. THC and CBD acted
    synergistically to inhibit cell proliferation. The treatment of
    glioblastoma cells with both compounds led to significant
    modulations of the cell cycle, induction of reactive oxygen species
    (free radicals) and apoptosis (programmed cell death).

    There were specific changes that were not observed with either
    compound individually, indicating that the signal transduction
    pathways affected by the combination treatment were unique.
    Researcher concluded that these "results suggest that the addition
    of cannabidiol to delta-9-THC may improve the overall
    effectiveness of delta-9-THC in the treatment of glioblastoma in
    cancer patients."

    (Source: Marcu JP, Christian RT, Lau D, Zielinski AJ, Horowitz
    MP, Lee J, Pakdel A, Allison J, Limbad C, Moore DH, Yount GL,
    Desprez PY, McAllister SD.Cannabidiol enhances the inhibitory
    effects of Delta9-tetrahydrocannabinol on human glioblastoma cell
    proliferation and survival. Mol Cancer Ther 2010;9(1):180-9.)
     
  2. #2 Poisongage, Jan 25, 2010
    Nobody finds this just a little bit exciting ??
     
  3. #3 justinsxc, Jan 26, 2010
    wow.. I find this awesome to be honest. Great find man! +rep
    it's amazing how dumb people are when it comes to marijuana... no one is open minded and thinks for themselves. let the research continue! :hello:
     
  4. #4 Poisongage, Jan 26, 2010
    I was beginning to think that nobody gave a shit in here no more...but here we go, finally somebody shows some interest in this amazing piece of news :)
     
  5. #5 goldhaze, Jan 26, 2010
    makes me glad i smoke :smoke:
     
  6. #6 TokeTheToke, Jan 26, 2010
    I can't seem to find the link for this. I want to show my friend. Any takers?
     
  7. #7 justinsxc, Jan 26, 2010
    Last edited by a moderator: Jan 26, 2010
    Yahoo! Groups

    if you go down to the 3rd article... but this isn't where it is originally found.
    these articles are nice to look at... the mmj yahoo group is pretty sweet.
    enjoy :smoke:
     
  8. #8 verbae, Jan 26, 2010
    :eek: awesome. :smoke:
     
  9. #9 Poisongage, Jan 26, 2010
    This bulletin has nothing to do with Yahoo, so don't link to them, that would be wrong.

    Here is the original link: International Association for Cannabis as Medicine

    I just posted a snippet of a bulletin i receive via mail every so often. That is why i didn't include any links in the OP. If you want to receive the bulletin, go here: IACM-Bulletin mailing list , and fill out the form.

    :)
     
  10. #10 Poisongage, Jan 26, 2010
    Very :D
     
  11. #11 justinsxc, Jan 26, 2010
    oops lol i didn't mean it came from it, just showed where u can read about it some more :p but that yahoo group is really interesting, check them out everyone! and good find with the actual link heh
     
  12. #12 Poisongage, Jan 26, 2010
    Not to worry, just wanted to share the source.
     
  13. #13 majicbunnie, Jan 26, 2010
    Fantastic find, thanks for posting. These results are very interesting and we will likely be hearing more about this soon if these results hold true.
     
  14. #14 EsotericXistenz, Jan 26, 2010
    Correct me if I'm wrong, but what I got from that is it stops the cancer cells from dividing? That is pretty exciting :hello:
     
  15. #15 Poisongage, Jan 26, 2010
    Not only that, but it kills the cancerous cells (apoptosis, programmed cell death) as well. That is the most exciting part :)
     
  16. #16 Poisongage, Jan 26, 2010
    Well this study is hardly the first of it's kind done with cannabis on cancer cells, but it's one of the more recent done on human tissue. There have been many studies in vitro that have shown that THC alone can kill cancer cells. It's no wonder then, that when THC has it's friends (Cannabidiol etc.) on board, it works even better.

    You should check out the research done by the Complutense University in Madrid. Google Dr. Guzman and his team and you will be surprised how far the research is coming along.
     

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