The Venture Brothers. Though I know a lot of people don't find it funny. I think you really need to have a good knowledge of obscure pop culture from the 80's and 90's to get most of the jokes.
i thought noone was going to mention that. i LOVE THE mIGHTY BOOSH!!! noel fielding is the shit!! Bob Fossil is really funny. Its like flight of the Conchords, but with weed, acid, and probably Ketamine. GREAT to watch when high. PLEASE if you're going to watch one thing on adult swim high, let it be the mighty boosh... For those of you who have Time Warner Cable, theres always free episodes on "Cutting Edge On Demand"
While speaking about Adult Swim, anyone remember their original Saturday Night anime lineup? I think it started with Yu Yu Hakusho, then Cowboy Bebop, then Mobile Suit Gundam, then Outlaw Star......there were some others too. That was by far the GREATEST lineup they ever had though. I think it was back in 2001 or 2002.
What's the show with the three kiddos, one of them is named Brendon. I've only seen a couple of episodes and all were very funny. In the last episode, the gang gained a lot of weight and were put on a diet. Brought me to tears.
Yeah, it's all about Harvey Birdman, I think my avatar should give that away. But as for shows that are currently on Adult Swim, Boondocks, Family Guy, Robot Chicken, in that order.