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I buy cartridges all the time and the number one thing I look at when buying them is the packaging. It should be sealed completely. For an example...
I live in Jersey and this is the OG way of rolling here. Dutch Masters Original, you gut it (break it) at the seam. Throw the tobacco out (guts)...
I think it really depends on the person. Ive had anxiety all my life but it progressively got worse over the years until I started smoking. For me...