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Asprin Sensitive Asthma/Samter`s Triad/Triad Asthma Cannabis ?

Discussion in 'Medical Marijuana Usage and Applications' started by glennjhill, Dec 21, 2015.

  1. #1 glennjhill, Dec 21, 2015
    I will quote form the Wikipedia article on this condition, that describes here below, the chemical chain reaction of this condition. the main treatment for it is to be desensitized to Aspirin, which is quite dangerous, due to possible excess bleeding, and because Aspirin is deadly to those of us who have this condition. So the question is IF and of the Non-THC chemical sin Cannabis might be helpful in controlling this condition ??


    If anyone has any ideas, or if anyone has knowledge of this condition being treated with medical Cannabis, pleas let me know ? Thanks ! Glenn



    "The disorder is thought to be caused by an anomaly in the arachidonic acid metabolizing cascade which leads to increased production of pro-inflammatory cysteinyl leukotrienes, a series of chemicals involved in the body's inflammatory response. When medications like NSAIDs or aspirin block the COX-1 enzyme, production of thromboxane and some anti-inflammatory prostaglandins
    is decreased, and in patients with aspirin-induced asthma this results
    in the overproduction of pro-inflammatory leukotrienes to causes severe
    exacerbations of asthma and allergy-like symptoms.[15][16][17][18][19][20] The underlying cause of the disorder is not fully understood, but there have been several important findings:

    Abnormally low levels of prostaglandin E2 (PGE2),
    which is protective for the lungs, has been found in patients with
    aspirin-induced asthma and may worsen their lung inflammation.[21]
    In addition to the overproduction of cystinyl leukotrienes, overproduction of 15-lipoxygenase-derived arachidonic acid metabolites viz., 15-hydroxyicosatetraenoic acid and eoxins by the eosinophils isolated from the blood of individuals with AERD; certain of these products may help promote the inflammatory response.[22][23]
    Overexpression of both the cysteinyl leukotriene receptor 1[24] and the leukotriene C4 synthase[25]
    enzyme has been shown in respiratory tissue from patients with
    aspirin-induced asthma, which likely relates to the increased response
    to leukotrienes and increased production of leukotrienes seen in the
    disorder.
    The attachment of platelets to certain leukocytes in the blood of
    patients with aspirin-sensitive asthma has also been shown to contribute
    to the overproduction of leukotrienes.[26]
    There may be a relationship between aspirin-induced asthma and TBX21, PTGER2, and LTC4S.[27]
    Eosinophils isolated from the blood of aspirin-induced asthma subjects (as well as severe asthmatic patients) greatly overproduce 15-hydroxyicosatetraenoic acid and eoxin C4 when challenged with arachidonic acid or calcium ionophore A23187,
    compared to the eosinophils taken from normal or mildly asthmatic
    subjects; aspirin treatment of eosinophils from aspirin intolerant
    subjects causes the cells to mount a further increase in eoxin
    production.[28]
    These results suggest that 15-lipoxygenase and certain of its
    metabolites, perhaps eoxin C4, as contributing to aspirin-induced asthma
    in a fashion similar to 5-lipoxygenase and its leukotriene metabolites."
     

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