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Inconclusive Drug Test
Posted 03 June 2010 - 01:10 AM
Similar Topics: Inconclusive Drug Test x
Posted 03 June 2010 - 03:39 AM
Edited by Neurosis, 03 June 2010 - 03:43 AM.
Posted 03 June 2010 - 06:47 AM
Posted 03 June 2010 - 07:54 AM
Anyway, this interested me to do a bit of reading into the metabolites.
A urine metabolic ratio of dextromethorphan and 3-... [Pharmacotherapy. 1999] - PubMed result
Dextromethorphan (DM) is metabolized in the body to dextrophan (DT) and 3-methoxymorphinan (3-MM) by cytochrome P450 (CYP) 2D6 and 3A4, respectively, and cyclosporine (CsA) is a known substrate of CYP3A4
(Just as a side note, apparently one metabolite binds irreversibly to neurons... spooky shit. Glad to say I've never tried PCP).
These two minor dihydroxylated metabolites were:cis-4-(4′-hydroxypiperidino)-4-phenylcyclohexanol andtrans-4-(4′-hydroxypiperidino)-4-phenylcyclohexanol. The four major metabolites used in this study and their HPLC retention times were c-PPC at 3.9 min, t-PPC at 6.05 min, PCHP at 7.4 min, PCHAP at 8.6 min, and PCP at 9.5 min (see fig.1).
I am hereby losing a lot of faith in the analytical world!
Edited by Neurosis, 03 June 2010 - 07:57 AM.
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