cannabinoid hypermesis

Goldmine · Apr 3, 2010

ever heard of it?

probably not. i know i hadnt...until i started trying to figure out why im so nauseous every goddamn morning.

and i guess i have it... its like i won the lottery, except theres no money involved, i just have to stop smoking cannabis.

i say its like winning the lotto bc evidently its quite rare...

a google search yields a few links....

-Cannabinoid hyperemesis: cyclical hyperemesis in association with chronic cannabis abuse

-Cannabinoid Hyperemesis or "Marijuana Morning Sickness" -- clinmed/2001110001v1 -- Clinical Medicine NetPrints

-Cannabinoid Hyperemesis Relieved by Compulsive Bathing

-Cannabinoid Hyperemesis - UK420

Cannabinoid hyperemesis syndrome: Clinical diagnosis of an underrecognised manifestation of chronic cannabis abuse

Cannabis is a common drug of abuse that is associated with various long-term and short-term adverse effects. The nature of its association with vomiting after chronic abuse is obscure and is underrecognised by clinicians. In some patients this vomiting can take on a pattern similar to cyclic vomiting syndrome with a peculiar compulsive hot bathing pattern, which relieves intense feelings of nausea and accompanying symptoms. In this case report, we describe a twenty-two year-old-male with a history of chronic cannabis abuse presenting with recurrent vomiting, intense nausea and abdominal pain.

In addition, the patient reported that the hot baths improved his symptoms during these episodes. Abstinence from cannabis led to resolution of the vomiting symptoms and abdominal pain. We conclude that in the setting of chronic cannabis abuse, patients presenting with chronic severe nausea and vomiting that can sometimes be accompanied by abdominal pain and compulsive hot bathing behaviour, in the absence of other obvious causes, a diagnosis of cannabinoid hyperemesis syndrome should be considered.

The long-term and short-term toxicity of cannabis abuse is associated with pathological and behavioural effects. However, cannabis has also been suggested to have therapeutic properties with anticonvulsive, analgesic, antianxiety and anti-emetic activities. Cannabis has also been used to treat anorexia in patients with acquired immunodeficiency syndrome. The actions of cannabis are mediated by specific cannabinoid receptors. The first of the cannabinoid receptors-CB-1-was identified in 1990 and this finding revolutionized the study of cannabinoid biology. Since then, a multitude of roles for the endogenous cannabinoid system has been proposed. A large number of endogenous cannabinoid neurotransmitters or endocannabinoids have been identified, and the CB-1 and CB-2 cannabinoid receptors have been characterized. The CB-1 receptors exert a neuromodulatory role in the central nervous system and enteric plexus. Cannabinoid type 2 receptors have an immunomodulatory effect and are located on tissues such as microglia. The presence of other receptors, transporters, and enzymes responsible for the synthesis or metabolism of endocannabinoids are being recognised at an extraordinary pace. Cannabinoids have a wide variety of effects on the body systems and physiologic states due to their actions on the receptors as well as direct toxic effects.

The anti-emetic effect of cannabinoids is largely mediated by CB-1 receptors in the brain and the intestinal tract, although some of their effect may also be receptor-independent. However, in this report, we were presented with the paradoxical effect of hyperemesis in a susceptible chronic cannabis abuser. Such a paradoxical response has previously only been demonstrated following acute toxicity to an intravenous injection of crude marijuana extract. Proposed mechanisms of cannabinoid hyperemesis include toxicity due to marijuana's long half-life, fat solubility, delayed gastric emptying, and thermoregulatory and autonomic disequilibrium via the limbic system. Cannabinoids are known to impair peristalsis in a dose-dependent manner, which can theoretically override the centrally mediated anti-emetic effects, thus leading to hyperemesis. It is not known why the hyperemesis syndrome surfaces after several years of cannabis abuse. The effects of cannabinoids on the functions of the thermoregulatory and autonomic mechanisms of the brain can lead to behavioural changes. Such effects might be the underlying mechanism for the compulsive hot bathing behaviour. There is also a supposition that the syndrome could represent a type of cyclic vomiting. Cyclic vomiting syndrome (CVS) in adults is now very well recognized, and it has been proposed that marijuana contributes to CVS. However, unlike the other forms of CVS, patients with cannabinoid hyperemesis are not likely to have a history of migraine or other psychosocial stressors and the peculiar behaviour of hot showers is unique to this syndrome.
Based on the published research and case reports, we propose the set of clinical characteristics for the diagnosis of cannabinoid hyperemesis syndrome shown in Table 2. Allen et al first noted this condition in a group of nineteen patients from Australia with chronic cannabis abuse and cyclical vomiting illness. An earlier case report by de Moore et al described a chronic cannabis abuser with psychogenic vomiting, which was complicated by spontaneous pneumomediastinum. Subsequent reports have identified similar clinical presentations. Given the high prevalence of chronic cannabis abuse worldwide and the paucity of reports in the literature, clinicians need to be more attentive to the clinical features of this underrecognised condition.
Click to expand...

wikipedia's heard of it too....

Cannabinoid hyperemesis syndrome - Wikipedia, the free encyclopedia

Cannabinoid hyperemesis syndrome is a disorder associated with long-term chronic cannabis use that is characterized by recurrent nausea, vomiting and colicky abdominal pain has been reported. These symptoms have been reported to be alleviated temporarily by taking a hot shower or bath or more permanently by abstaining from the use of cannabis. The syndrome is recognized by Allen and colleagues, and Sontineni and colleagues offered simplified clinical diagnostic criteria. The contributions made by these experts on the subject were pivotal in defining and characterizing the syndrome at a time when cannabis use is on the rise.

Cannabinoid hyperemesis was first reported from Adelaide hills of South Australia. Since the first recognition, several cases have been recognized worldwide. Cannabis is by far the most widely cultivated, trafficked and abused illicit drug. Half of all drug seizures worldwide are cannabis seizures. The geographical spread of those seizures is also global, covering practically every country of the world. About 147 million people, 2.5% of the world population, consume cannabis, compared with 0.2% consuming cocaine and 0.2% consuming opiates. In the present decade, cannabis abuse has grown more rapidly than cocaine and opiate abuse. The most rapid growth in cannabis abuse since the 1960s has been in developed countries in North America, Western Europe and Australia. Cannabis has become more closely linked to youth culture and the age of initiation is usually lower than for other drugs. Given such a widespread use of cannabis, the cannabinoid hyperemesis syndrome is afflicting large number of people and is in steady rise in its incidence.

Cannabis has been used recreationally for millennia. Some chronic negative health effects of the drug have only recently surfaced. The long-term and short-term toxicity of cannabis abuse is associated with pathological and behavioural effects leading to a wide variety of effects on the body systems and physiologic states. The phenomenon of cannabinoid hyperemesis and clinical diagnosis remained obscure until recently even though its features were beginning to be understood by leading physicians worldwide. In spite of these early reports, an uncertainty remained among the doctors and scientists regarding the existence of the cannabinoid hyperemesis syndrome. Sontineni and colleagues discuss the cannabinoid hyperemesis syndrome in their seminal paper to offer guidelines for the clinical diagnosis. The suggested criteria for the diagnosis are - Essential feature: 1) history of regular cannabis use for years; Major clinical features of syndrome: 2) severe nausea and vomiting, 3) vomiting that recurs in a cyclic pattern over months and 4) resolution of symptoms after stopping cannabis use. In addition diagnosis has supportive features of - 1) compulsive hot baths with symptom relief; 2) colicky abdominal pain; and 3) no evidence of gall bladder or pancreatic inflammation. Since the publication of these clinical guidelines, the syndrome is more easily recognized and treated.

Sontineni' scriteria for the diagnosis of "cannabinoid hyperemesis syndrome"

Essential- Cannabis use for years

Major- Severe nausea and vomiting,
Vomiting that recurs in a cyclic pattern over months,
Resolution of symptoms after stopping cannabis use.

Supportive- Compulsive hot baths with symptom relief,
Colicky abdominal pain,
No evidence of gall bladder or pancreatic inflammation

One of the key feature that makes cannabinoid hyperemesis syndrome relevant to the health care systems and physicians is its acute nature with intolerable nausea and vomiting, frequently requiring emergency room visits. Such emergency room visits often necessitate expensive diagnostic evaluations especially if the physicians awareness of the cannabinoid hyperemesis syndrome is lacking. In 2002, Americans made 110.2 million total visits to hospital emergency rooms with abdominal pain leading as a cause, a 23 percent increase over the 90 million visits made in 1992. It is evident to see such an enormous increase in the number of emergency room visits increase the health care costs. Given the implications and lack of clarity, it is of major significance that, leading researchers in the field offer simplified clinical diagnostic guidelines to improve the recognition of the syndrome and increase awareness at a time when cannabis abuse is on the rise . It is also suspected that cannabinoid hyperemesis that is observed in emergency room departments is probably the tip of the iceberg and a far larger numbers of milder symptoms do not come to attention in the broader community.

Various pathogenic mechanistic theories attempting to explain symptoms have been put forward. These theories fall into two themes; 1) dose dependent build up of cannabinoids and related effects of cannabinoid toxicity, and 2) the functionality of cannabinoid receptors in the brain and particularly in the hypothalamus (which regulates body temperature and the digestive system). But the mechanisms by which cannabis causes or controls nausea and the adverse consequences of long-term cannabis toxicity remain unknown and organic disease should not be ruled out as a possible cause.
The neurobiology of the compound has led to the discovery of an endogenous cannabinoid system . The therapeutic potential of cannabinoids has been recognized and these compounds are paradoxically utilized as anti-emetics. Several studies have demonstrated the therapeutic effects of cannabinoids for nausea and vomiting in the advanced stages of illnesses such as cancer and AIDS. Other therapeutic uses of cannabinoids are being demonstrated by controlled studies, including treatment of asthma and glaucoma, as an antidepressant, appetite stimulant, anticonvulsant and anti-spasmodic, research in this area should continue .
Click to expand...

im not really enjoying my showers any more than the next guy, i mean yea hot shower after all the vomiting definitley helps. buts is not like a compulsion. i have experenced some percieved difficulty in body temp regulation. like chills. but its also got something to do with my stomach. sometimes when i feel like this, the thought of food gives me chills. even though im fucking starving. and no i dont have an eating disorder, far from it.

usually when i wake up(always after about 5 or 6 hours of sleep, regardless of how tired i am) i just feel like ive got poision in my veins. so i go to the bathroom, grab my toothbrush, and start purging. except theres no food to expel, my food is digesting properly, which suggests im not actually sick. its all the wretching and contracting my stomach that helps i guess. i dunno.

what comes up is just like a white foam. or sometimes yellowsh stomach liquid. its never alot. but it always helps. well, sometimes it doesnt. somedays i just feel shitty all day, even if ive vmoited and smoked. most days through, i spend about 30 minutes wretching and vomiting, maybe hit the vape a few times, then shower and go about my day, and usually around noon i start to balance out and feel normal. this all started about 3 months ago. prior to that i hadnt ever experienced morning sickness.

basically my body isnt processing the shit fast enough due to over 7 years of heavy abuse (10 solid years of use), and its lingering, poisoning me. evertime i smoke im setting my self up for more pain the next day.... god only knows why this condition too so long to kick in...but its here now.

of course its possible that i do NOT have cannabanoid hypermesis. i have had some other health issues over the last two years, but im basically healthy rt now. the only way to know for sure will be to quit, and if it stops, welll then i'll know.

but i cant see my self ever quitting, i can certainly stop for awhile and only do it like once a week. a small price to pay to alleviate these hellish symptoms.

Buzzwell420 · Apr 3, 2010

I have canaboid hyphy osis

20000678 · Apr 3, 2010

Oh my god I'm so sorry. But you should try to get off the herb to see if it helps. I need to keep this in mind if this ever happens to me. Plus rep for the scientific evidence and quotes.

Forums

cannabinoid hypermesis

Goldmine *WEAK little LOSER boy *** 96 hrs no fap, 0 hrs no*
Gold Member

Buzzwell420 reefer brain

20000678 Not currently banned

Share This Page

Network

Forums

Help

Find Us On

Useful Searches

cannabinoid hypermesis

Goldmine WEAK little LOSER boy *** 96 hrs no fap, 0 hrs no Gold Member

Buzzwell420 reefer brain

20000678 Not currently banned

Share This Page

Goldmine *WEAK little LOSER boy *** 96 hrs no fap, 0 hrs no*
Gold Member