Weed, Tolerance And Its Impact

Hey GC whats up?
 
I am not sure if this is the right place for my question but whatever, I can't find a better place so here goes.
 
You know the way when you first start toking, it only takes a small amount to get you high? And you get super red eye's and increased heart rate etc?
 
Well, to me this is the cannabinoids taking effect on our endo-cannabinoid system, as current science would suggest.
 
But what I can't really understand scientifically, is why after smoking for a while our tolerance goes up and we no longer get red eye's as much or we can handle bigger hits without getting a higher heart rate?
 
For eg. A new toker having a small bowl might get a pretty racy hit, whereas veterans are hitting monstrous dabs of super potent wax and maybe getting the same kind of physical side effects.
 
Anyway, the next question that comes to mind is, if our tolerance to weed is affected through some sort of interaction with the endo-cannabinoid system, then can it become detrimental to our health?
 
Based on the evidence before me on these forums and in the world of weed, I would say no because it doesn't seem to affect anyone negatively and in fact it could be suggested that those who smoke a lot are in good health because of it, but this isn't really conclusive for me.
 
I'm thinking along the lines of, what if smoking a lot burns out our cannabinoid receptors (hence the increase in tolerance) and that could stop our bodies natural internal systems from working properly?
 
Or are the receptors that weed uses even part of our crucial physical self? I know that there are no receptors that affect life performing function such as heart and breathing etc, but what if the cannabinoid receptors play a role in regulating basic health and get tampered with through smoking weed?
 
Not trying to bum anyone out and sorry if it's a bit long winded but I would really love some solid input on this because currently I don't toke much but I might want to smoke more in the future and this issue makes me uncomfortable.
 
Thanks for reading. 

 

I've done some research on this subject and can happily add this to the discussion:
 
Linked below is how drugs effect our receptors (I think this is an important theory to understand and it seems a lot of people don't know about how this works):
 
http://www.erowid.org/ask/ask.php?ID=1794
 
Once we understand this, I think we can draw a few conclusions based on evidence currently available.
 
This is what i wrote down last night in my notepad:
 
"The suppressive effect on the endo cannibinoid system is such that it always
remains functioning even in the heaviest users and therefore still has the means
to function correctly as the abundance of receptors that are effected through
marijuana use create physiological effects that are more powerful than the
bodies average functions, i.e. the body has more than enough receptors to
achieve it's sustenance and will never lose it's ability to function based on
the evidence presented in the form of heavy habitual users.
Furthermore, small amounts do not induce a tolerance to the substance and
create no cannibinoid receptor suppression related risk, if they even exist
which doesn't seem to be the case."
 
This was me reasoning with myself that heavy use can't be that bad and also my intake is perfectly acceptable.

 

It seems like it's either a case of the body only allowing a certain amount of receptors to be locked down and then once it gets to a certain point it won't shut down any more of the receptors, or else the body can only create a certain amount of enzymes and then once it produces a certain amount it can't produce any more, so the receptors are always affected by the phytocannabinoids in weed and also our own endocannabinoids no matter how much a person smokes.
 
An interesting question for me now is, what is the relationship between enzymes that break down phytocannabinoids from weed and our bodies own indigenous endocannabinoids?