smoking and usage

ISmokeRock · #1 (**permalink**) 10-26-2007, 02:55 AM

http://www.foxnews.com/story/0,2933,304996,00.html

Marijuana is a potent antidepressant in low does, but worsens symptoms in high doses, according to a new study
THC, the active ingredient in marijuana, increases serotonin when smoked in low doses, similar to SSRI antidepressants, such as Prozac, according to researchers from McGill University and Le Centre de Recherche Fernand Seguin of Hôpital in Quebec and l'Université de Montréal in Montreal.
But at higher doses, the effect reverses itself and can actually worsen depression and other psychiatric conditions like psychosis.
During the study, published in the October 24 issue of The Journal of Neuroscience, laboratory rats were injected with the synthetic cannabinoid WIN55,212-2 and then tested with the Forced Swim test — a test to measure “depression” in animals.
The researchers observed an antidepressant effect of cannabinoids and an increased activity in the neurons that produce serotonin. However, increasing the cannabinoid dose beyond a set point completely undid the benefits, said Dr. Gabriella Gobbi of McGill University and Le Centre de Recherche Fernand Seguin of Hôpital Louis-H. Lafontaine.
  "So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed," she said in a news release.
The antidepressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, said Gobbi. They interact with the brain through structures called cannabinoid CB1 receptors.
The study demonstrated that these receptors have a direct effect on the cells producing serotonin, which is a neurotransmitter that regulates the mood, she said.
Because controlling the dosage of natural cannabis is difficult — particularly when it is smoked in the form of marijuana joints — using it directly as an antidepressant would be difficult, said the researchers.
"Excessive cannabis use in people with depression poses high risk of psychosis," said Gobbi.
Gobbi and her colleagues are focusing their research on a new class of drugs which enhance the effects of the brain's natural endo-cannabinoids.

Wugie · #2 (**permalink**) 10-26-2007, 10:55 PM

I can believe it

|2ebeL · #3 (**permalink**) 10-27-2007, 01:19 AM

dank legalize it

stoned stoner · #4 (**permalink**) 10-27-2007, 02:08 AM

I was depressed before I smoked and I stopped being depressed about the time I started smoking so I think it works.

Stratus · #5 (**permalink**) 10-27-2007, 04:22 AM

Its helped me in high doses, but I do smoke every day so.....

ResinRainbow · #6 (**permalink**) 10-27-2007, 04:23 AM

They used fake cannibinoids, so in my eyes, the whole thing is bunk.

Vikesfan911 · #7 (**permalink**) 10-27-2007, 04:36 AM

thats bomb.. but the only thing I don't really get is what is considered a "high dosage"

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#1 (permalink) 10-26-2007, 02:55 AM
ISmokeRock I don't smoke rock Join Date: Sep 2007 Location: Here, Now Posts: 808	Marijuana Improves Depression in Low Doses, Worsens It in High Doses, Study Says http://www.foxnews.com/story/0,2933,304996,00.html Marijuana is a potent antidepressant in low does, but worsens symptoms in high doses, according to a new study THC, the active ingredient in marijuana, increases serotonin when smoked in low doses, similar to SSRI antidepressants, such as Prozac, according to researchers from McGill University and Le Centre de Recherche Fernand Seguin of Hôpital in Quebec and l'Université de Montréal in Montreal. But at higher doses, the effect reverses itself and can actually worsen depression and other psychiatric conditions like psychosis. During the study, published in the October 24 issue of The Journal of Neuroscience, laboratory rats were injected with the synthetic cannabinoid WIN55,212-2 and then tested with the Forced Swim test — a test to measure “depression” in animals. The researchers observed an antidepressant effect of cannabinoids and an increased activity in the neurons that produce serotonin. However, increasing the cannabinoid dose beyond a set point completely undid the benefits, said Dr. Gabriella Gobbi of McGill University and Le Centre de Recherche Fernand Seguin of Hôpital Louis-H. Lafontaine. <!-- QUIGO --> <!-- QUIGO --> "So we actually demonstrated a double effect: At low doses it increases serotonin, but at higher doses the effect is devastating, completely reversed," she said in a news release. The antidepressant and intoxicating effects of cannabis are due to its chemical similarity to natural substances in the brain known as "endo-cannabinoids," which are released under conditions of high stress or pain, said Gobbi. They interact with the brain through structures called cannabinoid CB1 receptors. The study demonstrated that these receptors have a direct effect on the cells producing serotonin, which is a neurotransmitter that regulates the mood, she said. Because controlling the dosage of natural cannabis is difficult — particularly when it is smoked in the form of marijuana joints — using it directly as an antidepressant would be difficult, said the researchers. "Excessive cannabis use in people with depression poses high risk of psychosis," said Gobbi. Gobbi and her colleagues are focusing their research on a new class of drugs which enhance the effects of the brain's natural endo-cannabinoids. __________________

#2 (permalink) 10-26-2007, 10:55 PM
Wugie Wugalious Join Date: Sep 2007 Location: Florida Posts: 212	I can believe it

#3 (permalink) 10-27-2007, 01:19 AM
\|2ebeL Banned Join Date: Sep 2007 Posts: 111	dank legalize it

#4 (permalink) 10-27-2007, 02:08 AM
stoned stoner Registered User Join Date: Jul 2007 Location: new hampshire Posts: 322	I was depressed before I smoked and I stopped being depressed about the time I started smoking so I think it works. __________________ "America; first we fight for our freedom, then we make laws to take it away." - Alfred E. Newman

#5 (permalink) 10-27-2007, 04:22 AM
Stratus Permahigh Join Date: Oct 2006 Posts: 250	Its helped me in high doses, but I do smoke every day so..... __________________ So much on my mind I just can't recline Blastin holes in the night til she bled sunshine Breathe in, inhale vapors from bright stars that shine Breathe out, weed smoke retrace the skyline "My attorney had never been able to accept the notion, often espoused by former drug abusers, that you can get a lot higher without drugs than with them. And neither have I, for that matter."

#6 (permalink) 10-27-2007, 04:23 AM
ResinRainbow I can go twice as high Join Date: Oct 2007 Location: Hell Posts: 69	They used fake cannibinoids, so in my eyes, the whole thing is bunk.

#7 (permalink) 10-27-2007, 04:36 AM
Vikesfan911 fluffernuuutttttteerr Join Date: May 2007 Posts: 1,117	thats bomb.. but the only thing I don't really get is what is considered a "high dosage"

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