"First Pass Metabolism" - Why it's not working

First Pass Metabolism wiki

First pass metabolism, or the first pass effect, is when your liver basically intercepts the majority of the edible you've consumed, and breaks enough down to where the effect is diminished.

To avoid this, make sure your canna edible meal is not your first meal of the day. Make sure it's somewhere in the middle of your meal, and spread out as much as possible. For eample, I take a tablespoon and take half-tablespoons of butter and add it to my meal whilst I eat - it doesn't taste good(so?) but I can swish it down with water.

Orally consumed cannabis taken with other food and on a non-fast will greatly improve bioavailability of your cannabis, and substantially less will be broken down prematurely by the liver.

So, next time, eat it with a meal!

 

Bump.

 

When your liver intercepts and breaks down active cannabinoids, including d-9-THC, it also is converting some cannabinoids into breakdown products which still produce a measurable effect.

Effects of Smoked Cannabis and Oral Δ9-Tetrahydrocannabinol on Nausea and Emesis After Cancer Chemotherapy:A Review of State Clinical Trials

Acute effects of smoked marijuana and oral delta-9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects

Reinforcing and subjective effects of oral Δ9-THC and smoked marijuana in humans

Comparison of smoked marijuana and oral Δ9-tetrahydrocannabinol in humans


While I'm at it, this is interesting:

Effects of Expectancies on Subjective Responses to Oral Δ9-Tetrahydrocannabinol

Consistent with previous research using other drugs, subjects in the current experiment who expected to receive a cannabinoid reported greater pleasurable effects than subjects who did not have this expectancy. The results have implications for understanding the effects of cannabinoids when used in both recreational and clinical settings.

So when you're getting high, and you're expecting to get high, and want to get high, you get higher than if you didn't know you were about to be dosed up.

 

Like 25 minutes after your meal if you don't want it to dilute into part of your meal. If you do, then eat it right after.

 

It depends if your edible is infused into fat or not. If it's not infused into a fat, you'll get exteremly poor bioavailability, so you want to take it with a meal. If it's infused into olive oil or butter or something, It's best to eat your edible dose about an hour and ah alf after a REGULAR sized meal, otherwise the oil will dilute into the rest of your meal, and youll never have a significant peak, as it takes your body extra time to digest the edible oil.
I wrote this before, and might help you

The more fat, the more diluted the cannabinoids get into all the fat, and your body has to digest more to feel an effect, and it slows down your high, while making it longer

let me give you an example. I made oil once, same as always, but I ended up going to a buffet about 2 hours later. I had eaten a good sized meal earlier in the day, so my body was still digesting it when I ate the edible. By the time I was eating at the buffet, I was slightly high, high enough to eat a grip (beef ribs high fat ftw) BUT I diluted the rest of the dose into the 10 beef ribs I had eaten! I didn't have a significant peak, but I was slightly high all night until past 2am

so think about your body as a machine, and you want it to use up the oil in a shorter period of time so your blood cannabinoid concentrations spike, rather than dilute it with other food and prolong the delivery and lessen the peak

want the strongest peak? Use as little oil as possible, and as much cannabis as will fit submerged. Finally, eat it one and a half to two hours after your last meal, and dont eat anything until at least 3 hours passed. Thats how I have my best highs. Again, this is only if the cannabis is infused into a lipid, which causes it to be absorbed thru your lymphatic system. If it's not infused into a fat, the bioavailability drops and your first pass metabolism will probably eat it up. Remember! Never eat an edible to break a fast (as breakfast or after going overnight without eating). Always eat one meal during the day before the edible dosage.

 

From the first post of this thread

Oral Intake of a Cannabinoid Together with a Meal Improved Bioavailability '

Researchers of Monash University in Victoria, Australia, investigated the reason why the oral bioavailability of a synthetic cannabinoid receptor agonist (CRA13) was significantly improved if taken together with a meal rich in fat. Oral bioavailability was assessed in human volunteers and in dogs with and without a meal. Food had a substantial positive effect on the oral bioavailability of CRA13 in human volunteers and in dogs. This cannabinoid is highly lipophilic (soluble in fat) as other cannabinoids including THC.

The absolute bioavailability of the cannabinoid was low in fasted dogs (8-20 per cent), in spite of good absorption (72-75 per cent of radio-labelled CRA13 recovered in the systemic circulation). In fed dogs, bioavailability increased to 47.5 per cent and the majority (43.7 per cent) of the dose was absorbed via the lymphatic system of the intestine. Researchers concluded that the positive food effect for CRA13 does not appear to result from increased absorption. Rather the increase in bioavailability was stimulated via almost complete transport into the lymph, in turn resulting in a reduction in first-pass metabolism. In fasted dogs most of the cannabinoid was metabolised, i.e. changed to inactive compounds, at once in the liver before reaching the whole body, while the liver was bypassed in fed animals.

--

It takes up to 3 hours, so you mightve smoked right at the right time that it was digesting and letting the cannabinoids into your bloodstream

http://forum.grasscity.com/incredib...aleos-potent-decarboxylated-cannabis-oil.html

Decarboxylate, cook until the cannabis turns brown, eat after a meal.

If you are taking heroic doses, like 4 grams or more, it's advisable to eat a small meal with the edible.