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Originally Posted by Storm Crow  Let's start with a couple of 2009 THC studies-
Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2
Cannabinoid Receptor1 http://cancerres.aacrjournals.org/cg...61/15/5784.pdf
They did the usual mouse injected with human cancer cells study and showed that the tumors regressed (gross photos included) and then.... "Finally, we analyzed the tumors of 2 patients enrolled in a clinical trial aimed at investigating the effect of THC on recurrent glioblastoma multiforme. The patients were subjected to intracranial THC administration, and biopsies were taken before and after the treatment. "
Their conclusions-
" These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers."
"THC-induced autophagy promotes the apoptotic death of cancer cells."
Now a second study done on the same tumor patients also revealed that THC slowed the growth of the blood vessels that fed the gliomas. Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas -- Blázquez et al. 64 (16): 5617 -- Cancer Research
Their findings-
" Here, we report that cannabinoid administration inhibits the VEGF pathway in cultured glioma cells, in glioma-bearing mice, and in two patients with glioblastoma multiforme."
So THC slowed the chemical process that promotes the growth of blood vessels to cancers in petri dishes, in mice, AND in humans.
So just how are these results like these "a bandaid over symptoms" or the "sideeffects of being high"?  The tumors shrank, the blood vessels growth slowed. |
All those say is that some amount of THC (could be ridiculously high amount, its hard to tell in many of your sources since a lot of the ones I got to I was redirected to the newest journal edition or a simple abstract) directly injected into a brain tumor through the skull, I don't know about you but I usually just smoke to get high..., can maybe cause shrinking of brain tumors. So would lots of medicines or poisons as well. There isn't enough research there to tell you the extent of the promise these drugs would have. Not to mention, there are probably drugs in trials at this stage that do this
better than THC anyways.
LEast to say, this is in MICE. They can grow human ears on the back of mice too.
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Originally Posted by Storm Crow Vocabulary for the "science challenged" autophagic/ autophagy= literally self-eating apoptopic/apoptosis = cell death intracranial= directly into the brain vascular endothelial growth factor (VEGF)= stuff that makes the blood vessels grow faster. glioma = brain cancer glioblastoma multiforme = nasty type of brain cancer that often comes back |
Most of that was discernable from context clues and my training in medical terminology, but thank you.
Quote:
Originally Posted by Storm Crow
And lastly just for you, Dale-
micromolar - A concentration of 1/1,000,000 (one millionth) molecular weight per liter (mol/L). Not a heck of a lot, in other words.
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Which is still useless information until we know it is comprable to the THC purity and amount in the users brain tumor after smoking a medical joint or something of the like. Injecting pure THC at high levels into a tumor making it die doesnt mean smoking weed will stop your brain tumors. It says to me that pharma companies will look at THCs powers in this rite and will synthesize and refine and partner it with other drugs into a pill or injection for shrinking tumors. None of which has to do with the current medicinal marijuana system in place now.
There isn't enough to know what may come of as far as practical non-smoking uses medically for cannabis, yet there is a medical marijuana community consisting of thousands of diagnosis that agree their symptoms are better when
smoking or otherwise using marijuana to get high. Seems to me that the common link is symptom alleviation, which would lead to such widespread use. And we all know that the symptoms are being relived by being high or the side effects of being high indirectly.