Quote:
CB1
Cannabinoid receptor type 1 (CB1) receptors are thought to be the most widely expressed G-protein coupled receptors in the brain. This is due to endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.
They are also found in other parts of the body. For instance, in the liver, activation of the CB1 receptor is known to increase de novo lipogenesis,[6] Activation of presynaptic CB1 receptors is also known to inhibit sympathetic innervation of blood vessels and contributes to the suppression of the neurogenic vasopressor response in septic shock.[7]
CB2
CB2 receptors are mainly expressed on T cells of the immune system, on macrophages and B cells, and in hematopoietic cells. They also have a function in keratinocytes, and are expressed on mouse pre-implantation embryos. It is also expressed on peripheral nerve terminals. In the brain, they are mainly expressed by microglial cells, where their role remains unclear.
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I read about making opiates stronger with less of a dose, and many people said that they ate certain food a few days before orally taking opiates, so as to increase the production of a certain enzyme in the liver which causes less of the chemical to be wasted, and thus leading it to be metabolized to enter the brain.
I would say that this is similar and can possibly cause more of the THC to be delivered to your brain receptors, or even make your receptors 'stronger' or something if you were to take an enzyme supplement [for CB1], or perhaps vitamin C to increase your immune system [for CB2], although it says the role remains unclear.
Quote:
Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound.
After the receptor is engaged, multiple intracellular signal transduction pathways are activated. At first, it was thought that cannabinoid receptors mainly inhibited the enzyme adenylate cyclase (and thereby the production of the second messenger molecule cyclic AMP), and positively influenced inwardly rectifying potassium channels (=Kir or IRK).[8] However, a much more complex picture has appeared in different cell types, implicating other potassium ion channels, calcium channels, protein kinase A and C, Raf-1, ERK, JNK, p38, c-fos, c-jun and many more.[8] |
Looks like taking minerals could cause more reactions with THC, and less of it to be wasted, but I'm not sure about actually increasing the receptor sites, but then again, things can grow and die much faster on a cellular level than in larger terms.