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Depending on how long you leave it broken up and how you store it. It can affect potency not to much, but it can. That's because all the thc is within the trichromes and when you break it up you loosen that crystal from what's keeping it tied down so it can float away, if you keep it contained though it's no problem. I often break up a lot at once and put it right in this magnetic box that has a screen in it and then another magnectic piece attached to the bottom with a glass sheet that the crystal collects on. Good for homemade hash or crystal bowls and joints. (crystal=kief for any who use that term)
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