[beamish]

isn't that stuff like.. extremely harmful?
yeah, stick to the safer (lol!) hallucinogens.

Let me explain. I'm a user @ another forum where mainly very intelligent [not that WTM users aren't intelligent, but basically @ this forum, if you don't know what your'e talking about, your'e gonna be confused] users and drug abusers. Well, I mentioned mine and WTM's experimentation into DPH use recently, and I learned a very ugly truth:
Diphenhydramine Is VERY Dangerous.

Quote:
All H1 histamine antagonists are reversible competitive inhibitors of histamine receptors. First-generation H1-receptor blockers also are potent competitive inhibitors of muscarinic receptors and may cause anticholinergic syndrome (eg, sinus tachycardia, dry skin, dry mucous membranes, dilated pupils, ileus, urinary retention, agitated delirium). In addition, antihistamines disrupt cortical neurotransmission and block fast sodium channels. These effects exacerbate sedation and seizure activity and may cause cardiac conduction delays manifested by widening of the QRS interval. The phenothiazine class of antihistamines (eg, promethazine) has alpha-adrenergic blocking activity and may cause hypotension.


Quote:
n the US: The American Association of Poison Control Centers Toxic Exposure Surveillance System (AAPCC-TESS) annual report for 2004 ascribes 72,762 exposures to either H1 or H2 blockers. H2 blockers were associated with 8,659 exposures, while H1 blockers were associated with 64,103. A total of 24,498 patients exposed to either H1 or H2 blockers were treated in a healthcare facility. Diphenhydramine was the most common antihistamine exposure, with 29,501 reports being made to poison centers.


Quote:
Of all antihistamine exposures reported to US poison control centers in 2004 (AAPCC-TESS data), 7049 (7.4%) resulted in moderate-to-major toxicity and 55 (0.076%) resulted in fatality. The vast majority of fatalities (54%) were associated with diphenhydramine.


Quote:
First-generation H1-receptor antagonists, such as diphenhydramine, may be particularly dangerous because they may cause pronounced agitation leading to rhabdomyolysis and acidosis. Also, a quinidinelike sodium channel blocking effect, and at high doses a potassium channel blocking effect, may cause delayed conduction and repolarization and contribute to ventricular dysrhythmias.


Quote:
In a review of 136 patients with diphenhydramine overdose, somnolence, lethargy, and coma were the most common findings, occurring in approximately 55% of reported overdoses.


^^^Keep in mind anything above a manufacterer recomended dose is a "overdose."

Quote:
Acute extrapyramidal movement disorders, severe anxiety reactions, and toxic psychosis also have been reported.


Quote:
In a report of chronic abuse, diphenhydramine resulted in withdrawal symptoms. A 34-year-old patient with schizophrenia had been ingesting approximately 800 mg of diphenhydramine twice daily for one month to achieve sedation and euphoria. Diphenhydramine was tapered to 600 mg daily in divided doses over the first 3 days of hospitalization and then was reduced more slowly with the last dose being administered on the ninth day of hospitalization. The patient developed recurrence of insomnia during the withdrawal period and increased daytime restlessness, irritability, and excessive blinking; extrapyramidal symptoms and psychosis were absent.


^^^It's even addicting.

Quote:
Sinus tachycardia, ventricular tachycardia, torsades de points, cardiogenic shock, and hypertension have all been reported following overdose with antihistamines. Sinus tachycardia is the most common toxic cardiovascular effect from antihistamines with prominent anticholinergic properties. Antihistamines with anticholinergic effects and the potential to cause quinidinelike conduction abnormalities include diphenhydramine, chlorpheniramine, pyrilamine, and certain phenothiazines.


Quote:
These drugs slow sodium conduction through cardiac sodium channels and result in decreased conduction and myocardial contractility. Rarely, myocardial pump failure occurs with large overdoses.


Quote:
Pulmonary findings: Pulmonary congestion was the most common finding on autopsy in a review of 76 reported deaths from diphenhydramine between 1946 and 2003. This is presumably of a cardiogenic origin due to cardiovascular collapse and ventricular failure, although the coincidence of myocardial toxicity is not reported.


Source

When I was first shown this [and trust me there are hundreds more articles like this] I denied it. I used everything I knew about the way the body worked to "disprove" what the users over there claimed. But it's when I heard their stories, first hand stories [many of them are doctors or specialists in one form or another] of themselves or anothers seizuring, going into comas, hearts stopping, ETC ETC, was when I was convinced.

It's your body guys, I'm trying not to make your own decisions for you, but for your own sake, discontinue all large doses of Diphenhydramine. [Ironically, there are no problems when the medicine is used as it's supposed to be used.]

Let me recap before someone goes "BUT EROWID SAID THE LD50 WAS 500MG/KG." Yes, that's how much it's going to take to actually die from the DPH. But what the DPH does to your body has a very very strong chance of killing you.

QFT