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Depends, what do you mean by 'fucking with the lighting'?
It does matter.
If you are flowering, 12/12, and all the sudden, you decide hell, for a day I awnt to go 18/6 for no apparent reason, and the next day back to 12/12 that will stress your plant and fuck with it, therfore promoting hermies and other such problems.
If during veggie you cahnge it from 20/4, to 18/6, that wont bother it, its just during flowering.
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