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Originally Posted by Wikipedia
Speculations
Several speculative and as yet untested hypotheses suggest that endogenous DMT, produced in the human brain, is involved in certain psychological and neurological states. As DMT is naturally produced in small amounts in the brains and other tissues of humans, and other mammals,[11] some believe it plays a role in promoting the visual effects of natural dreaming, and also near-death experiences and other mystical states. A biochemical mechanism for this was proposed by the medical researcher JC Callaway, who suggested in 1988 that DMT might be connected with visual dream phenomena, where brain DMT levels are periodically elevated to induce visual dreaming and possibly other natural states of mind. [12]
Dr. Rick Strassman, while conducting DMT research in the 1990s at the University of New Mexico, advanced the theory that a massive release of DMT from the pineal gland prior to death or near death was the cause of the near death experience (NDE) phenomenon. Several of his test subjects reported NDE-like audio or visual hallucinations. His explanation for this was the possible lack of panic involved in the clinical setting and possible dosage differences between those administered and those encountered in actual NDE cases.
Several subjects also reported contact with 'other beings', alien like, insectoid and reptilian in nature, in technological environments[4] where the subjects were 'probed', 'tested' and sometimes even 'manipulated' by these 'beings' (see Abduction phenomenon).
In the 1950s, the endogenous production of psychoactive agents was considered to be a potential explanation for the hallucinatory symptoms of some psychiatric diseases as the transmethylation hypothesis.[13](see also Adrenochrome). Unfortunately, this hypothesis does not account for the natural presence of endogenous DMT in otherwise normal humans, not to mention rats and other laboratory animals. The proposal by Dr. Callaway was the first to suggest a useful function for the endogenous production of DMT; i.e. to facilitate the visual phenomenon of normal dreaming.
Ethical concerns do not allow for the testing of this hypothesis in humans, as the biological samples must come from the living human brain.
Writers on DMT include Terence McKenna and Jeremy Narby, though most scientists who study psychedelic drugs treat their writings with skepticism. McKenna writes of his experiences with DMT in which he encounters entities he describes as "Self-Transforming Machine Elves". McKenna believed DMT to be a tool that could be used to enhance communication and allow for communication with other-worldly entities. Other users report visitation from external intelligences attempting to impart information. These Machine Elf experiences are said to be shared by many DMT users. From a researcher's perspective, perhaps best known is Rick Strassman's DMT: The Spirit Molecule (ISBN 0-89281-927-8);[14] Strassman speculated that DMT is made in the pineal gland, largely because the necessary constituents(see methyltransferases) needed to make DMT are found in the pineal gland. However, no one has looked for DMT in the pineal yet. It's possible Strassman thought that because DMT falls in the large class of chemicals called Tryptamines, which includes Serotonin, LSD, Melatonin (a hormone the Pineal Gland does produce), and Psilocybin.
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